Integrated view of Vibrio cholerae in the Americas

Domman, D, Quilici, M, Dorman, MJ, Njamkepo, E, Mutreja, A, Mather, AE, Delgado, G, Morales-Espinosa, R, Grimont, PAD, Lizárraga-Partida, ML, Bouchier, C, Aanensen, DM, Kuri-Morales, P, Tarr, CL, Dougan, G, Parkhill, J, Campos, J, Cravioto, A, Weill, F and Thomson, NR. 2017. Integrated view of Vibrio cholerae in the Americas. [Online]. Figshare. Available from: https://doi.org/10.6084/m9.figshare.5427253.v1

Domman, D, Quilici, M, Dorman, MJ, Njamkepo, E, Mutreja, A, Mather, AE, Delgado, G, Morales-Espinosa, R, Grimont, PAD, Lizárraga-Partida, ML, Bouchier, C, Aanensen, DM, Kuri-Morales, P, Tarr, CL, Dougan, G, Parkhill, J, Campos, J, Cravioto, A, Weill, F and Thomson, NR. Integrated view of Vibrio cholerae in the Americas [Internet]. Figshare; 2017. Available from: https://doi.org/10.6084/m9.figshare.5427253.v1

Domman, D, Quilici, M, Dorman, MJ, Njamkepo, E, Mutreja, A, Mather, AE, Delgado, G, Morales-Espinosa, R, Grimont, PAD, Lizárraga-Partida, ML, Bouchier, C, Aanensen, DM, Kuri-Morales, P, Tarr, CL, Dougan, G, Parkhill, J, Campos, J, Cravioto, A, Weill, F and Thomson, NR (2017). Integrated view of Vibrio cholerae in the Americas. [Data Collection]. Figshare. https://doi.org/10.6084/m9.figshare.5427253.v1

Description

Latin America has experienced two of the largest cholera epidemics in modern history; one in 1991 and the other in 2010. However, confusion still surrounds the relationships between globally circulating pandemic Vibrio cholerae clones and local bacterial populations. We used whole-genome sequencing to characterize cholera across the Americas over a 40-year time span. We found that both epidemics were the result of intercontinental introductions of seventh pandemic El Tor V. cholerae and that at least nine lineages local to the Americas are associated with disease that differs epidemiologically from epidemic cholera. Our results consolidate historical accounts of pandemic cholera with data to show the significance of local lineages, presenting an integrated view of cholera that is important to the design of future disease control strategies.

Methods

Data capture method	Experiment
Date (Date published in a 3rd party system)	26 November 2017
Language(s) of written materials	English

People & Groups

Data Creators	Domman, D, Quilici, M, Dorman, MJ, Njamkepo, E, Mutreja, A, Mather, AE, Delgado, G, Morales-Espinosa, R, Grimont, PAD, Lizárraga-Partida, ML, Bouchier, C, Aanensen, DM, Kuri-Morales, P, Tarr, CL, Dougan, G, Parkhill, J, Campos, J, Cravioto, A, Weill, F and Thomson, NR
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Participating Institutions	London School of Hygiene & Tropical Medicine, Institut Pasteur, Biotechnology and Biological Sciences Research Council