Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result"

Hanifa, Y, Fielding, K, Grant, AD and Churchyard, GJ. 2016. Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result". [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.284.

Hanifa, Y, Fielding, K, Grant, AD and Churchyard, GJ. Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result" [Internet]. London School of Hygiene & Tropical Medicine; 2016. Available from: https://doi.org/10.17037/DATA.284.

Hanifa, Y, Fielding, K, Grant, AD and Churchyard, GJ (2016). Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result". [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.284.

Description

The World Health Organization recommends regular tuberculosis screening of HIV-positive individuals with Xpert MTB/RIF as the first diagnostic test. Further evaluation of those who are HIV-positive and Xpert-negative comprises clinical reassessment, chest radiograph (if available), sputum for mycobacterial culture, and treatment with antibiotic if clinically indicated. The aim of our study was to describe the diagnostic yield from an immediate repeat sputum tested with Xpert, compared to sequential further investigation guided by South African recommendations , amongst HIV-positive adults in South Africa being investigated for TB whose initial sputum Xpert result is negative. It was a sub-study of “Xpert for people attending HIV/AIDS care: test or review?” (XPHACTOR), a prospective cohort study evaluating a risk-based algorithm to prioritise Xpert testing amongst adults attending for routine HIV care in South Africa. This dataset contains data for 227 adults attending for routine HIV care who have an initial negative sputum Xpert result. It includes basic demographics, TB diagnoses, mycobacteriology and chest radiograph results. Data was collected for the purpose of HIV and TB research and can only be reused for related research, in accordance with the participant consent agreement.

Methods

Description of data capture

A systematic sample of adults attending for HIV care was enrolled to the XPHACTOR study. This substudy was restricted to those at highest risk of tuberculosis (CD4<200 cells/mm3 or unknown) and a negative initial sputum Xpert result. At attendance for the Xpert result, a repeat sputum sample was stored, and further investigations facilitated per national guidelines. Participants were reviewed monthly, with reinvestigation if indicated, for at least three months, when sputum and blood were cultured for mycobacteria, and the stored sputum tested using Xpert. We defined tuberculosis as “confirmed” if Xpert, line probe assay or Mycobacterium tuberculosis culture within six months of enrolment were positive, and “clinical” if tuberculosis treatment was started without microbiological confirmation.

Data capture method

Interview: Face-to-face, Questionnaire: Fixed form - Paper

Data Collection Period

From	To
September 2012	March 2014

Date (Date submitted to LSHTM repository)

August 2016

Geographical area covered (offline during plugin upgrade)

North Latitude	East Longitude	South Latitude	West Longitude
-25.6124	28.47	-26.3482	27.8272

Language(s) of written materials

English

People & Groups

Data Creators	Hanifa, Y, Fielding, K, Grant, AD and Churchyard, GJ
Associated roles	Hanifa, Y (Co-Investigator), Fielding, K (Co-Investigator), Chihota, VN (Co-Investigator), Adonis, L (Co-Investigator), Charalambous, S (Co-Investigator), Foster, N (Co-Investigator), Karstaedt, A (Co-Investigator), McCarthy, K (Co-Investigator), Nicol, MP (Co-Investigator), Ndlovu, NT (Project Manager), Sinanovic, E (Co-Investigator), Sahid, F (Other), Stevens, W (Co-Investigator), Vassall, A (Co-Investigator), Churchyard, GJ (Principal Investigator) and Grant, AD (Principal Investigator)
LSHTM Faculty/Department	Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre	TB Centre
Participating Institutions	TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom, The Aurum Institute, South Africa, National Health Laboratory Services, South Africa, University of Cape Town, South Africa

Projects

Funders

Project	Funder	Grant Number	Funder URI
Xpert MTB/RIF for people attending HIV care: an interventional cohort study to guide rational implementation (XPHACTOR)	Bill and Melinda Gates Foundation	OPP1034523	http://dx.doi.org/10.13039/100000865