Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result"
, Grant, AD and Churchyard, GJ
(2016).
Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result".
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.284.
The World Health Organization recommends regular tuberculosis screening of HIV-positive individuals with Xpert MTB/RIF as the first diagnostic test. Further evaluation of those who are HIV-positive and Xpert-negative comprises clinical reassessment, chest radiograph (if available), sputum for mycobacterial culture, and treatment with antibiotic if clinically indicated. The aim of our study was to describe the diagnostic yield from an immediate repeat sputum tested with Xpert, compared to sequential further investigation guided by South African recommendations , amongst HIV-positive adults in South Africa being investigated for TB whose initial sputum Xpert result is negative. It was a sub-study of “Xpert for people attending HIV/AIDS care: test or review?” (XPHACTOR), a prospective cohort study evaluating a risk-based algorithm to prioritise Xpert testing amongst adults attending for routine HIV care in South Africa. This dataset contains data for 227 adults attending for routine HIV care who have an initial negative sputum Xpert result. It includes basic demographics, TB diagnoses, mycobacteriology and chest radiograph results. Data was collected for the purpose of HIV and TB research and can only be reused for related research, in accordance with the participant consent agreement.
Additional Information
Participant data was collected on the basis that it would be used for ethically-approved HIV and TB related research only. Requesters will be required to provide information on their research and sign a Data Transfer Agreement as a condition of access.
Keywords
Tuberculosis, Diagnostic tests, HIV infections, South AfricaParent Collection(s)
- note_stack XPHACTOR datasets
| Item Type | Dataset |
|---|---|
| Description of data capture | A systematic sample of adults attending for HIV care was enrolled to the XPHACTOR study. This substudy was restricted to those at highest risk of tuberculosis (CD4<200 cells/mm3 or unknown) and a negative initial sputum Xpert result. At attendance for the Xpert result, a repeat sputum sample was stored, and further investigations facilitated per national guidelines. Participants were reviewed monthly, with reinvestigation if indicated, for at least three months, when sputum and blood were cultured for mycobacteria, and the stored sputum tested using Xpert. We defined tuberculosis as “confirmed” if Xpert, line probe assay or Mycobacterium tuberculosis culture within six months of enrolment were positive, and “clinical” if tuberculosis treatment was started without microbiological confirmation. |
| Capture method | Interview: Face-to-face, Questionnaire: Fixed form - Paper |
| Collection Period |
From To September 2012 March 2014 |
| Date | August 2016 |
| Geographical area covered (offline during plugin upgrade) |
North Latitude East Longitude South Latitude West Longitude -25.6124 28.47 -26.3482 27.8272 |
| Language(s) of written materials | English |
| Creator(s) |
Hanifa, Y, Fielding, K, Grant, AD and Churchyard, GJ
|
| Associated roles | Hanifa, Y (Co-Investigator), Fielding, K (Co-Investigator), Chihota, VN (Co-Investigator), Adonis, L (Co-Investigator), Charalambous, S (Co-Investigator), Foster, N (Co-Investigator), Karstaedt, A (Co-Investigator), McCarthy, K (Co-Investigator), Nicol, MP (Co-Investigator), Ndlovu, NT (Project Manager), Sinanovic, E (Co-Investigator), Sahid, F (Other), Stevens, W (Co-Investigator), Vassall, A (Co-Investigator), Churchyard, GJ (Principal Investigator) and Grant, AD (Principal Investigator) |
| LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
| Research Centre | TB Centre |
| Participating Institutions | TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom, The Aurum Institute, South Africa, National Health Laboratory Services, South Africa, University of Cape Town, South Africa |
| Funders |
Project Funder Grant Number Funder URI Xpert MTB/RIF for people attending HIV care: an interventional cohort study to guide rational implementation (XPHACTOR) OPP1034523 http://dx.doi.org/10.13039/100000865 |
| Date Deposited | 16 Apr 2018 15:33 |
| Last Modified | 02 Jun 2025 12:02 |
| Publisher | London School of Hygiene & Tropical Medicine |
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subject - Data
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lock - Restricted to Request access for all
- Data Sharing Agreement
- Available under Data Sharing Agreement
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info - Unlinked Repeat Xpert dataset - MS Excel and CSV format. Data can be reused for HIV and TB related research only
folder_zip - application/zip
- folder_info
- 264B
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subject - Documentation
- Creative Commons: Attribution
- Available under Creative Commons: Attribution 3.0
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info - Information sheet and consent form
picture_as_pdf - application/pdf
- folder_info
- 450kB
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subject - Documentation
- Creative Commons: Attribution
- Available under Creative Commons: Attribution 3.0
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info - Codebook containing variable definitions
html - text/html
- folder_info
- 32kB
