Data for "Life course malaria exposure and SARS-CoV-2 Sero-epidemiology in Ugandan adolescents: a longitudinal study nested in a birth cohort"
; Webb, E; Nkurunungi, G; Natukunda, A; Nassuna, J; Nakyesige, R; Nayebare, D and Baine, C
(2026).
Data for "Life course malaria exposure and SARS-CoV-2 Sero-epidemiology in Ugandan adolescents: a longitudinal study nested in a birth cohort".
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00005044.
This data was collected from a longitudinal study nested within the Entebbe Mother and Baby Study birth cohort in Uganda. Adolescents were enrolled and followed up 6 and 12 months later. Blood samples were collected at each visit for SARS-CoV-2 serology. Malaria exposure was defined using prospectively collected data on clinical malaria (from birth to 10 years), asymptomatic parasitaemia at annual visits, and antibody responses to Plasmodium falciparum merozoite surface protein 2 (PfMSP-2) and apical membrane antigen 1 (PfAMA-1). The primary outcome was SARS-CoV-2 seropositivity, based on spike and nucleocapsid IgG responses, with seropositivity cut-offs derived from pre-pandemic samples. Secondary outcomes, including antibody concentrations and symptomatic PCR-confirmed disease, were explored.
Additional Information
Research data made available upon request, subject to agreement to a 'light touch' licence to store data securely at all times.
Keywords
Malaria; SARS-CoV-2; Longitudinal data| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Field observation: Participant, Lab observation: Participant |
| Collection Period |
From To 30 April 2011 31 December 2022 |
| Date | 25 February 2026 |
| Language(s) of written materials | English |
| Creator(s) |
Zirimenya, L; Elliott, AM; Webb, E; Nkurunungi, G; Natukunda, A; Nassuna, J; Nakyesige, R; Nayebare, D and Baine, C
|
| LSHTM Faculty/Department |
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research MRC/UVRI and LSHTM Uganda Research Unit |
| Research Centre | Malaria Centre |
| Research Group | Immunomodulation and Vaccines Group |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom; MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda; Uganda Virus Research Institute, Entebbe, Uganda |
| Funders |
Project Funder Grant Number Funder URI VAnguard NIHR134531 http://dx.doi.org/10.13039/501100000272 |
| Date Deposited | 02 Mar 2026 15:32 |
| Last Modified | 02 Mar 2026 15:32 |
| Publisher | London School of Hygiene & Tropical Medicine |
Data / Code
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subject - Data
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lock - Restricted to Request access for all
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copyright - Available under Data Sharing Agreement
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info - CoHost main study data
folder_zip - application/zip
- folder_info
- 237B
Documentation
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subject - Documentation
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- Available under Creative Commons: Attribution 4.0
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info - Codebook for CoHost study data
html - text/html
- folder_info
- 44kB
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subject - Documentation
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- Available under Creative Commons: Attribution 4.0
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info - User guide for CoHost study data
html - text/html
- folder_info
- 5kB
