Simms, V
and Ferrand, R
(2024).
VITALITY: Vitamin D for adolescents with HIV to reduce musculoskeletal morbidity and immunopathology - Baseline Data.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00003868.
and Ferrand, R
(2024).
VITALITY: Vitamin D for adolescents with HIV to reduce musculoskeletal morbidity and immunopathology - Baseline Data.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00003868.
The VITamin D for AdoLescents with HIV to reduce musculoskeletal morbidity and ImmunopaThologY (VITALITY) trial is a phase III two-site, individually randomised, double-blinded, placebo-controlled trial. Participants were randomised 1:1 to receive weekly vitamin D and daily 500mg calcium carbonate supplementation or placebo for 48 weeks. Participants were followed for a further 48 weeks to investigate the sustainability of intervention effect. 842 children aged 11-19 years with perinatally-acquired HIV resident in greater Harare (Zimbabwe site) or within Lusaka (Zambia site) were recruited. The baseline dataset contains information on the participants' living environment, health status, received treatments, exercise levels, and other information.
Additional Information
Applications require approval by representatives from the country where data was collected. To apply for access, complete the application form, outlining the data variables in which you are interested. If approved, applicants will need to sign a data transfer agreement outlining permitted use and security conditions. Consult codebook for further information.
Keywords
HIV; Bone and mineral metabolism; Adolescence; Puberty; Zimbabwe| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Description of data capture | Participants completed a researcher-administered questionnaire on demographic and social characteristics and medical history, and a dietary assessment. They gave a blood sample for CD4 and HIV viral load tests (full blood count in Zambia). They had anthropometric measurements (height, sitting height and weight in both countries; waits, hip, calf, triceps circumfererence, skinfold thickness, Tanita bioimedance assessment Bodpod in Zambia). They had a total body and lumbar spine DXA scan. Those in Zimbabwe had a pQCT scan and a hand X-ray using the iDXA. A blood sample was taken for measurements of vitamin D pathway metabolites, bone turnover markers and iPTH, and for additional immunology studies in Zambia. 123 participants in each country had a rectal swab. |
| Capture method | Interview: Face-to-face, Lab observation, Physical measurements and tests |
| Collection Period |
From To 4 February 2021 23 November 2021 |
| Date | 11 June 2024 |
| Language(s) of written materials | English, Shona |
| Creator(s) |
Simms, V and Ferrand, R
|
| Associated roles | Bandason, T (Data Manager) and Filteau, S (Researcher) |
| LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & International Health (2023-) Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
| Research Group | The Health Research Unit Zimbabwe (THRUZIM) |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom; Biomedical Research and Training Institute, Zimbabwe; University Teaching Hospital Lusaka, Lusaka, Zambia |
| Funders |
Project Funder Grant Number Funder URI VITamin D for AdoLescents with HIV to reduce musculoskeletal morbidity and ImmunopaThologY (VITALITY): an individually randomised, double-blinded placebo-controlled triaL RIA2018CO-2512 http://dx.doi.org/10.13039/501100001713 |
| Date Deposited | 20 Aug 2024 16:08 |
| Last Modified | 29 Jan 2026 10:41 |
| Publisher | London School of Hygiene & Tropical Medicine |
Explore Further
- Vitamin D3 and calcium carbonate supplementation for adolescents with HIV to reduce musculoskeletal morbidity and immunopathology (VITALITY trial): study protocol for a randomised placebo-controlled trial.
- Patterns of linear growth among children and adolescents living with HIV on antiretroviral therapy in Zimbabwe and Zambia
- Methods for measuring body composition in Zambian adolescents living with HIV.
Data / Code
VITALITY_baseline_data.txt
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subject - Data
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lock - Restricted to Request access for all
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copyright - Available under Data Sharing Agreement
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info - VITALITY trial baseline dataset
description - text/plain
- folder_info
- 51B
Documentation
VITALITY_baseline_data_codebook.html
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subject - Documentation
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- Available under Creative Commons: Attribution 4.0
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info - Codebook for VITALITY trial baseline dataset
html - text/html
- folder_info
- 119kB
3868_UserGuide.html
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subject - Documentation
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- Available under Creative Commons: Attribution 4.0
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info - User guide for VITALITY trial baseline dataset
html - text/html
- folder_info
- 5kB
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