Support files for: The acceptability of the AMBITION-cm treatment regimen for HIV-associated cryptococcal meningitis: findings from a qualitative methods study of participants and researchers in Botswana and Uganda

Lawrence, D

; Moshashane, N; Nabaggala, G; Maphane, L; Harrison, T; Meya, D; Jarvis, J

(2022). Support files for: The acceptability of the AMBITION-cm treatment regimen for HIV-associated cryptococcal meningitis: findings from a qualitative methods study of participants and researchers in Botswana and Uganda. [Dataset]. London School of Hygiene & Tropical Medicine, London, United Kingdom. 10.17037/DATA.00003106.

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The AMBITION-cm trial for HIV-associated cryptococcal meningitis had a qualitative methods study embedded within the AMBITION-cm sites in Botswana and Uganda. Eligible trial participants, surrogate decision makers, and researchers at both sites were contacted to participate in a set of in-depth interviews (IDIs). This fileset contains a set of collection tools produced and used for the in-depth interviews, as well as the participation information sheets, consent forms and interview schedules for each group.

Keywords

HIV; Cryptococcal meningitis; AmBisome; Human Immunodeficiency Virus

Item Type	Dataset
Resource Type	Resource Type Resource Description Dataset Interview guides
Description of data capture	We embedded a qualitative methods study within the AMBITION-cm sites in Botswana and Uganda. Interviews were conducted and combined with direct observations. Consecutively eligible trial participants were approached to participate in two in-depth interviews (IDIs). The first IDI took place at least six weeks into the ten-week trial and the other at least four weeks after the final trial appointment. Secondly, consecutively eligible surrogate decision makers were approached to participate in a single in-depth interview at least six weeks after having provided consent for a trial participant. Finally, we interviewed researchers working on the AMBITION-cm trial on a single occasion. Altogether, we interviewed 38 trial participants, 20 surrogate decision makers, and 31 researchers. Interviews were transcribed, translated, and analysed thematically.
Capture method	Interview, Observation
Collection Period	From To January 2020 June 2021
Date	22 September 2022
Geographical area covered (offline during plugin upgrade)	North East South West 1.45952 34.1473 -0.73757 32.1258 -24.3184 24.6551 -25.7518 22.9852
Language(s) of written materials	English
Creator(s)	Lawrence, D ; Ssali, A ; Moshashane, N; Nabaggala, G; Maphane, L; Harrison, T; Meya, D; Jarvis, J and Seeley, J
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Dept of Clinical Research Faculty of Public Health and Policy > Dept of Global Health and Development
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; MRC/UVRI & LSHTM Uganda Research Institute, Entebbe, Uganda; St George's University, London, United Kingdom; Infectious Diseases Institute, Makerere University, Kampala, Uganda
Funders	Project Funder Grant Number Funder URI AMBITION-cm trial European and Developing Countries Clinical Trials Partnership TRIA 2015-1092 http://dx.doi.org/10.13039/501100001713 AMBITION-cm trial Joint Global Health Trials MR/P006922/1 UNSPECIFIED LEOPARD Study National Institute for Health and Care Research RP-2017-08-ST2-012 http://dx.doi.org/10.13039/501100000272
Date Deposited	17 Oct 2022 09:39
Last Modified	18 Sep 2025 14:54
Publisher	London School of Hygiene & Tropical Medicine

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The acceptability of the AMBITION-cm treatment regimen for HIV-associated cryptococcal meningitis: Findings from a qualitative methods study of participants and researchers in Botswana and Uganda.

Study Instrument

LEOPARD-Botswana next of kin PIS.docx

subject: Study Instrument
: Available under Creative Commons: Attribution 4.0
info: Participation information sheets for trial participants in Botwana. Version 2, 02 Sept 2020
description: application/vnd.openxmlformats-officedocument.wordprocessingml.document
folder_info: 402kB

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LEOPARD-Botswana participant PIS.docx

subject: Study Instrument
: Available under Creative Commons: Attribution 4.0
info: Participation information sheets for trial participants in Botwana. Version 2, 02 Sept 2020
description: application/vnd.openxmlformats-officedocument.wordprocessingml.document
folder_info: 402kB

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LEOPARD-Botswana next of kin consent.docx

subject: Study Instrument
: Available under Creative Commons: Attribution 4.0
info: Consent forms for surrogate decision makers in Botswana. Version 1, 28 June 2019
description: application/vnd.openxmlformats-officedocument.wordprocessingml.document
folder_info: 402kB

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LEOPARD-Botswana participant consent.docx

subject: Study Instrument
: Available under Creative Commons: Attribution 4.0
info: Consent forms for trial participants in Botswana. Version 1, 28 Jun 2019
description: application/vnd.openxmlformats-officedocument.wordprocessingml.document
folder_info: 404kB

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LEOPARD-All sites next of kin IDI schedule.docx

subject: Study Instrument
: Available under Creative Commons: Attribution 4.0
info: Interview schedule for surrogate decision makers from all sites. Version 1, 28 Jun 2019
description: application/vnd.openxmlformats-officedocument.wordprocessingml.document
folder_info: 199kB

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LEOPARD-All sites participant IDI schedule.docx

subject: Study Instrument
: Available under Creative Commons: Attribution 4.0
info: Interview schedule for trial participants from all sites. Version 1, 28 Jun 2019
description: application/vnd.openxmlformats-officedocument.wordprocessingml.document
folder_info: 202kB

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LEOPARD-All sites researcher IDI schedule.docx

subject: Study Instrument
: Available under Creative Commons: Attribution 4.0
info: Interview schedule for researchers from all sites. Version 1, 28 Jun 2019
description: application/vnd.openxmlformats-officedocument.wordprocessingml.document
folder_info: 403kB

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LEOPARD-All sites researcher PIS.docx

subject: Study Instrument
: Available under Creative Commons: Attribution 4.0
info: Participation information sheets for researchers from all sites. Version 1, 28 Jun 2019
description: application/vnd.openxmlformats-officedocument.wordprocessingml.document
folder_info: 403kB

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LEOPARD-All sites researcher consent.docx

subject: Study Instrument
: Available under Creative Commons: Attribution 4.0
info: Consent forms for researchers from all sites. Version 1, 28 Jun 2019
description: application/vnd.openxmlformats-officedocument.wordprocessingml.document
folder_info: 402kB

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