Autopsy Prevalence of Tuberculosis and Other Potentially Treatable Infections among Adults with Advanced HIV Enrolled in Out-Patient Care in South Africa: Lesedi Kamoso study data

Karat, AS, Omar, T, von Gottberg, A, Tlali, M, Chihota, VN, Churchyard, GJ, Fielding, KL, Johnson, S, Martinson, NA, McCarthy, K, Wolter, N, Wong, EB, Charalambous, S and Grant, AD. 2016. Autopsy Prevalence of Tuberculosis and Other Potentially Treatable Infections among Adults with Advanced HIV Enrolled in Out-Patient Care in South Africa: Lesedi Kamoso study data. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.122.

Karat, AS, Omar, T, von Gottberg, A, Tlali, M, Chihota, VN, Churchyard, GJ, Fielding, KL, Johnson, S, Martinson, NA, McCarthy, K, Wolter, N, Wong, EB, Charalambous, S and Grant, AD. Autopsy Prevalence of Tuberculosis and Other Potentially Treatable Infections among Adults with Advanced HIV Enrolled in Out-Patient Care in South Africa: Lesedi Kamoso study data [Internet]. London School of Hygiene & Tropical Medicine; 2016. Available from: https://doi.org/10.17037/DATA.122.

Karat, AS, Omar, T, von Gottberg, A, Tlali, M, Chihota, VN, Churchyard, GJ, Fielding, KL, Johnson, S, Martinson, NA, McCarthy, K, Wolter, N, Wong, EB, Charalambous, S and Grant, AD (2016). Autopsy Prevalence of Tuberculosis and Other Potentially Treatable Infections among Adults with Advanced HIV Enrolled in Out-Patient Care in South Africa: Lesedi Kamoso study data. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.122.

Description

Early mortality among HIV-positive adults starting antiretroviral therapy (ART) remains high in resource-limited settings, with tuberculosis (TB) the leading cause of death. However, current methods to estimate TB-related deaths are inadequate and most autopsy studies do not adequately represent those attending primary health clinics (PHCs). The TB Fast Track study aimed to determine the autopsy prevalence of TB and other infections in adults enrolled at South African PHCs in the context of a pragmatic trial of empiric TB treatment. This dataset contains basic demographic information and lab investigation results of 34 HIV-positive individuals who died after study enrolment. This includes MGIT culture and Xpert MTB/RIF; aerobic and fungal cultures; and histological findings

Methods

Description of data capture

Adults with CD4 150 cells/L, not on ART or TB treatment, were enrolled to TB Fast Track and followed up for at least six months. Minimally-invasive autopsy (MIA) was conducted as soon as possible after death. Lungs, liver, and spleen were biopsied; blood, CSF, and urine aspirated; and bronchoalveolar lavage fluid obtained. Samples underwent mycobacterial, bacterial, and fungal culture; molecular testing (including Xpert MTB/RIF); and histological examination.

Data capture method

Other

Data Collection Period

From	To
10 October 2013	3 June 2015

Date (Completed)

6 May 2016

Geographical area covered

North Latitude	East Longitude	South Latitude	West Longitude
-23.7159	30.7727	-26.3042	27.2791

Language(s) of written materials

English

People & Groups

Data Creators	Karat, AS, Omar, T, von Gottberg, A, Tlali, M, Chihota, VN, Churchyard, GJ, Fielding, KL, Johnson, S, Martinson, NA, McCarthy, K, Wolter, N, Wong, EB, Charalambous, S and Grant, AD
LSHTM Faculty/Department	Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre	TB Centre
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom, The Aurum Institute, Johannesburg, South Africa, Foundation for Professional Development, Pretoria, South Africa, The University of the Witwatersrand, Johannesburg, South Africa, National Health Laboratory Services, South Africa, Perinatal HIV Research Unit, Soweto, Johannesburg, South Africa, Johns Hopkins Center for TB Research