10.17037/DATA.122
Early mortality among HIV-positive adults starting antiretroviral therapy (ART) remains high in resource-limited settings, with tuberculosis (TB) the leading cause of death. However, current methods to estimate TB-related deaths are inadequate and most autopsy studies do not adequately represent those attending primary health clinics (PHCs). The TB Fast Track study aimed to determine the autopsy prevalence of TB and other infections in adults enrolled at South African PHCs in the context of a pragmatic trial of empiric TB treatment.
This dataset contains basic demographic information and lab investigation results of 34 HIV-positive individuals who died after study enrolment. This includes MGIT culture and Xpert MTB/RIF; aerobic and fungal cultures; and histological findings
Adults with CD4 150 cells/L, not on ART or TB treatment, were enrolled to TB Fast Track and followed up for at least six months. Minimally-invasive autopsy (MIA) was conducted as soon as possible after death. Lungs, liver, and spleen were biopsied; blood, CSF, and urine aspirated; and bronchoalveolar lavage fluid obtained. Samples underwent mycobacterial, bacterial, and fungal culture; molecular testing (including Xpert MTB/RIF); and histological examination.
Human population
Majority of participant identifiable information removed prior to upload. Birth date and day/month of date of death was removed at the request of LSHTM RDM Service.
Ethics approval obtained from London School of Hygiene & Tropical Medicine and partner institutions.
Tuberculosis, HIV, Autopsy, Mortality, Disease prevalence, Minimally invasive autopsy, Cause of death, Opportunistic infections, Infectious Diseases, HIV diagnosis and management, Tuberculosis diagnosis and management, tuberculosis treatment, Cryptococcal meningitis, Pneumonia, Bacterial and viral diseases
English
| Project name | Funder/sponsor | Grant number |
| TB fast track: effect of a point-of-care TB test-and-treat algorithm on early mortality in people with HIV accessing ART | Bill & Melinda Gates Foundation | OPP1083118 |
| Role | Forename | Surname | Faculty / Dept | Institution |
| Data Creator | Aaron S. | Karat | London School of Hygiene & Tropical Medicine | |
| Data Creator | Tanvier | Omar | National Health Laboratory Service (NHLS), South Africa | |
| Data Creator | Anne | von Gottberg | National Institute for Communicable Diseases | |
| Data Creator | Mpho | Tlali | Aurum Institute | |
| Data Creator | Violet N. | Chihota | Aurum Institute | |
| Data Creator | Gavin J. | Churchyard | Epidemiology & Population Health > Infectious Disease Epidemiology | London School of Hygiene & Tropical Medicine |
| Data Creator | Katherine L. | Fielding | Epidemiology & Population Health > Infectious Disease Epidemiology | London School of Hygiene & Tropical Medicine |
| Data Creator | Suzanne | Johnson | Foundation for Professional Development | |
| Data Creator | Neil A. | Martinson | Perinatal HIV Research Unit (PHRU) | Chris Hani Baragwanath Hospital, Soweto, Johannesburg |
| Data Creator | Kerrigan | McCarthy | National Institute for Communicable Diseases | |
| Data Creator | Nicole | Wolter | National Institute for Communicable Diseases | |
| Data Creator | Emily B. | Wong | KwaZulu-Natal Research Institute for TB-HIV (K-RITH) | |
| Data Creator | Salome | Charalambous | Aurum Institute | |
| Data Creator | Alison D. | Grant | Infectious & Tropical Diseases > Clinical Research | London School of Hygiene & Tropical Medicine |
| Filename | Description | Access status | Licence |
| MIA_Data_Summary | Data collected to investigate early mortality among HIV-positive adults starting antiretroviral therapy (ART) | Controlled access | Data sharing agreement |
| MIA_Data_Summary_codebook | Codebook for MIA dataset | Open access | Creative Commons Attribution (CCBY) |
| 0243-UserGuide | User guide for MIA dataset (this document) | Open access | Creative Commons Attribution (CCBY) |