Autopsy Prevalence of Tuberculosis and Other Potentially Treatable Infections among Adults with Advanced HIV Enrolled in Out-Patient Care in South Africa: Lesedi Kamoso study data
, Omar, T, von Gottberg, A, Tlali, M, Chihota, VN, Churchyard, GJ, Fielding, KL, Johnson, S, Martinson, NA, McCarthy, K, Wolter, N, Wong, EB, Charalambous, S and Grant, AD
(2016).
Autopsy Prevalence of Tuberculosis and Other Potentially Treatable Infections among Adults with Advanced HIV Enrolled in Out-Patient Care in South Africa: Lesedi Kamoso study data.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.122.
Early mortality among HIV-positive adults starting antiretroviral therapy (ART) remains high in resource-limited settings, with tuberculosis (TB) the leading cause of death. However, current methods to estimate TB-related deaths are inadequate and most autopsy studies do not adequately represent those attending primary health clinics (PHCs). The TB Fast Track study aimed to determine the autopsy prevalence of TB and other infections in adults enrolled at South African PHCs in the context of a pragmatic trial of empiric TB treatment.
This dataset contains basic demographic information and lab investigation results of 34 HIV-positive individuals who died after study enrolment. This includes MGIT culture and Xpert MTB/RIF; aerobic and fungal cultures; and histological findings
Additional Information
Documentation converted from text to HTML on 11 Sep 2024.
Keywords
Tuberculosis, HIV, Autopsy, Mortality, Disease prevalence, Minimally invasive autopsy, Cause of death, Opportunistic infections, Infectious Diseases, HIV diagnosis and management, Tuberculosis diagnosis and management, tuberculosis treatment, Cryptococcal meningitis, Pneumonia, Bacterial and viral diseases| Item Type | Dataset |
|---|---|
| Description of data capture | Adults with CD4 150 cells/L, not on ART or TB treatment, were enrolled to TB Fast Track and followed up for at least six months. Minimally-invasive autopsy (MIA) was conducted as soon as possible after death. Lungs, liver, and spleen were biopsied; blood, CSF, and urine aspirated; and bronchoalveolar lavage fluid obtained. Samples underwent mycobacterial, bacterial, and fungal culture; molecular testing (including Xpert MTB/RIF); and histological examination. |
| Capture method | Other |
| Collection Period |
From To 10 October 2013 3 June 2015 |
| Date | 6 May 2016 |
| Geographical area covered (offline during plugin upgrade) |
North Latitude East Longitude South Latitude West Longitude -23.7159 30.7727 -26.3042 27.2791 |
| Language(s) of written materials | English |
| Creator(s) |
Karat, AS, Omar, T, von Gottberg, A, Tlali, M, Chihota, VN, Churchyard, GJ, Fielding, KL, Johnson, S, Martinson, NA, McCarthy, K, Wolter, N, Wong, EB, Charalambous, S and Grant, AD
|
| LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
| Research Centre | TB Centre |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom, The Aurum Institute, Johannesburg, South Africa, Foundation for Professional Development, Pretoria, South Africa, The University of the Witwatersrand, Johannesburg, South Africa, National Health Laboratory Services, South Africa, Perinatal HIV Research Unit, Soweto, Johannesburg, South Africa, Johns Hopkins Center for TB Research |
| Funders |
Project Funder Grant Number Funder URI |
| Date Deposited | 21 Oct 2016 13:53 |
| Last Modified | 11 Sep 2024 15:33 |
| Publisher | London School of Hygiene & Tropical Medicine |
-
subject - Data
-
lock - Restricted to Request access for all
- Data Sharing Agreement
- Available under Data Sharing Agreement
-
info - Data collected to investigate early mortality among HIV-positive adults starting antiretroviral therapy (ART)
description - text/plain
- folder_info
- 56B
-
subject - Documentation
-
- Available under Creative Commons: Attribution 4.0
-
info - Codebook for MIA summary dataset
html - text/html
- folder_info
- 47kB
-
subject - Documentation
-
- Available under Creative Commons: Attribution 4.0
-
info - User guide for MIA summary dataset
html - text/html
- folder_info
- 7kB
