Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection"

Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ. 2015. Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection". [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.104.

Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ. Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection" [Internet]. London School of Hygiene & Tropical Medicine; 2015. Available from: https://doi.org/10.17037/DATA.104.

Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ (2015). Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection". [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.104.

Methods

Description of data capture

This study was nested within a 12 month microbicide feasibility study of 970 HIV-negative women aged 18–44 years working in bars, hotels, and other food and recreational facilities in the three towns of Geita, Shinyanga and Kahama in northwestern Tanzania from 2008-2010. Participants enrolled in the sub-study were followed up three times a week for 4 weeks (12 visits total). At enrolment, interviews were carried out to obtain information about sexual behaviour, vaginal practices, current contraception, and STI symptoms. On the first and last visit (visits 1 & 12), a clinical and colposcopic examination were performed; cervical and vaginal swabs were collected to test for vaginal pH and reproductive tract infections (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, bacterial vaginosis, and yeast); and a CVL was obtained for the detection of Herpes simplex virus, types 1 and 2 (HSV), prostate-specific antigen (PSA) to measure seminal plasma exposure in the last 48 hours, soluble immune proteins, haemoglobin and white blood cells (WBCs). During visits 2 to 11, a shortened interview was conducted to obtain updated sexual behaviours and intravaginal practices. A brief clinical examination was performed to obtain vaginal swabs for testing vaginal pH, bacterial vaginosis and yeast, and a CVL for the detection of HSV, PSA, soluble immune proteins, haemoglobin and WBCs. Urine was collected at every visit to test for pregnancy and menstrual cycle phase. If a woman was menstruating, no genital samples were obtained on that visit. No blood samples were collected; however laboratory data from the main cohort on HSV antibody status, HIV status and syphilis results were available for the statistical analysis and methods have been reported in a previous study. Colposcopy was carried out by trained clinicians according to the CONRAD/WHO revised manual for the Standardization of Colposcopy for the Evaluation of Vaginal Products

Data capture method

Interview: Face-to-face, Physical measurements and tests

Data Collection Period

From	To
2008	2010

Date (Completed)

24 November 2015

Geographical area covered

North Latitude	East Longitude	South Latitude	West Longitude
-2.8534	32.4068	-2.99853	32.2067
-3.15914	34.3908	-3.57692	33.9139
-3.50223	33.0251	-4.10522	32.3103

Language(s) of written materials

English

People & Groups

Data Creators	Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ
LSHTM Faculty/Department	Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom, St George's, University of London, London, United Kingdom, University of Liverpool, Liverpool, United Kingdom, Imperial College London, London, United Kingdom, National Institute for Medical Research, London, United Kingdom

Projects

Funders

Project	Funder	Grant Number	Funder URI
Women’s Health Project: A HIV prevention trial feasibility study	European and Developing Countries Clinical Trials Partnership	UNSPECIFIED	http://dx.doi.org/10.13039/501100001713
Women’s Health Project: A HIV prevention trial feasibility study	Medical Research Council	UNSPECIFIED	http://dx.doi.org/10.13039/501100000265
Women’s Health Project: A HIV prevention trial feasibility study	International Partnership For Microbicides	UNSPECIFIED	UNSPECIFIED
Women’s Health Project: A HIV prevention trial feasibility study	Department for International Development	UNSPECIFIED	http://dx.doi.org/10.13039/501100000278

Additional Information

Date Deposited	09 May 2016 11:11
Last Modified	31 May 2022 10:46
Publisher	London School of Hygiene & Tropical Medicine

Downloads

Data / Code

eis_biomarkers Download

Filename: eis_biomarkers.txt

Description: Anonymised dataset containing information on sexual behaviour, vaginal practices, current contraception, STI symptoms, as well as results of a clinical and colposcopic examination

Licence: