Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ. 2015. Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection". [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.104.
Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ. Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection". [Internet] LSHTM Data Compass. London, United Kingdom: London School of Hygiene & Tropical Medicine; 2015. Available from: https://doi.org/10.17037/DATA.104.
Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ (2015). Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection". [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.104.
Description
An anonymised dataset containing details of a sub-study of 100 HIV-negative women in 2009. This sub-study was part of a microbicide feasibility study in North-West Tanzania that was carried out between 2008-2010. It contains information on sexual behaviour, vaginal practices, current contraception, STI symptoms, as well as results of a clinical and colposcopic examination
Keywords
Description of data capture | This study was nested within a 12 month microbicide feasibility study of 970 HIV-negative women aged 18–44 years working in bars, hotels, and other food and recreational facilities in the three towns of Geita, Shinyanga and Kahama in northwestern Tanzania from 2008-2010. Participants enrolled in the sub-study were followed up three times a week for 4 weeks (12 visits total). At enrolment, interviews were carried out to obtain information about sexual behaviour, vaginal practices, current contraception, and STI symptoms. On the first and last visit (visits 1 & 12), a clinical and colposcopic examination were performed; cervical and vaginal swabs were collected to test for vaginal pH and reproductive tract infections (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, bacterial vaginosis, and yeast); and a CVL was obtained for the detection of Herpes simplex virus, types 1 and 2 (HSV), prostate-specific antigen (PSA) to measure seminal plasma exposure in the last 48 hours, soluble immune proteins, haemoglobin and white blood cells (WBCs). During visits 2 to 11, a shortened interview was conducted to obtain updated sexual behaviours and intravaginal practices. A brief clinical examination was performed to obtain vaginal swabs for testing vaginal pH, bacterial vaginosis and yeast, and a CVL for the detection of HSV, PSA, soluble immune proteins, haemoglobin and WBCs. Urine was collected at every visit to test for pregnancy and menstrual cycle phase. If a woman was menstruating, no genital samples were obtained on that visit. No blood samples were collected; however laboratory data from the main cohort on HSV antibody status, HIV status and syphilis results were available for the statistical analysis and methods have been reported in a previous study. Colposcopy was carried out by trained clinicians according to the CONRAD/WHO revised manual for the Standardization of Colposcopy for the Evaluation of Vaginal Products | ||||||||||||||||
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Data capture method | Interview: Face-to-face, Physical measurements and tests | ||||||||||||||||
Data Collection Period |
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Date (Completed) | 24 November 2015 | ||||||||||||||||
Geographical area covered |
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Language(s) of written materials | English |
Data Creators | Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ |
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LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
Participating Institutions | London School of Hygiene & Tropical Medicine, St George's, University of London, University of Liverpool, Imperial College London, National Institute for Medical Research |
Funders |
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Depositor | Suzanna Francis |
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Date Deposited | 09 May 2016 11:11 |
Last Modified | 20 Jan 2021 12:56 |
Publisher | London School of Hygiene & Tropical Medicine |
Downloads
Data
Restricted to: Request access for all
Filename: dataset.zip
Description: De-identified dataset available on request
Licence: Data Sharing Agreement
Content type: Dataset
File size: 22B
Mime-Type: application/zip
Documentation
Filename: DataDictionary_PDF.pdf
Description: Description of variables contained within the dataset
Content type: Textual content
File size: 581kB
Mime-Type: application/pdf
Filename: DataDictionary_XLSX.xlsx
Description: Data dictionary in MS Excel format, as produced by data creator
Content type: Textual content
File size: 16kB
Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet