Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection"
Francis, SC
, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ
(2015).
Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection".
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.104.
, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ
(2015).
Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection".
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.104.
An anonymised dataset containing details of a sub-study of 100 HIV-negative women in 2009. This sub-study was part of a microbicide feasibility study in North-West Tanzania that was carried out between 2008-2010. It contains information on sexual behaviour, vaginal practices, current contraception, STI symptoms, as well as results of a clinical and colposcopic examination
Additional Information
This dataset cannot be made available via a repository due to ethical restrictions. Interested researchers may submit request for de-identified data to Saidi.Kapiga@lshtm.ac.uk.
Keywords
Cytokines, Chemokines, HIV, Microbicides, Vaccines, Sub-Saharan| Item Type | Dataset |
|---|---|
| Description of data capture | This study was nested within a 12 month microbicide feasibility study of 970 HIV-negative women aged 18–44 years working in bars, hotels, and other food and recreational facilities in the three towns of Geita, Shinyanga and Kahama in northwestern Tanzania from 2008-2010. Participants enrolled in the sub-study were followed up three times a week for 4 weeks (12 visits total). At enrolment, interviews were carried out to obtain information about sexual behaviour, vaginal practices, current contraception, and STI symptoms. On the first and last visit (visits 1 & 12), a clinical and colposcopic examination were performed; cervical and vaginal swabs were collected to test for vaginal pH and reproductive tract infections (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, bacterial vaginosis, and yeast); and a CVL was obtained for the detection of Herpes simplex virus, types 1 and 2 (HSV), prostate-specific antigen (PSA) to measure seminal plasma exposure in the last 48 hours, soluble immune proteins, haemoglobin and white blood cells (WBCs). During visits 2 to 11, a shortened interview was conducted to obtain updated sexual behaviours and intravaginal practices. A brief clinical examination was performed to obtain vaginal swabs for testing vaginal pH, bacterial vaginosis and yeast, and a CVL for the detection of HSV, PSA, soluble immune proteins, haemoglobin and WBCs. Urine was collected at every visit to test for pregnancy and menstrual cycle phase. If a woman was menstruating, no genital samples were obtained on that visit. No blood samples were collected; however laboratory data from the main cohort on HSV antibody status, HIV status and syphilis results were available for the statistical analysis and methods have been reported in a previous study. Colposcopy was carried out by trained clinicians according to the CONRAD/WHO revised manual for the Standardization of Colposcopy for the Evaluation of Vaginal Products |
| Capture method | Interview: Face-to-face, Physical measurements and tests |
| Collection Period |
From To 2008 2010 |
| Date | 24 November 2015 |
| Geographical area covered (offline during plugin upgrade) |
North Latitude East Longitude South Latitude West Longitude -2.8534 32.4068 -2.99853 32.2067 -3.15914 34.3908 -3.57692 33.9139 -3.50223 33.0251 -4.10522 32.3103 |
| Language(s) of written materials | English |
| Creator(s) |
Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ
|
| LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom, St George's, University of London, London, United Kingdom, University of Liverpool, Liverpool, United Kingdom, Imperial College London, London, United Kingdom, National Institute for Medical Research, London, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI Women’s Health Project: A HIV prevention trial feasibility study UNSPECIFIED http://dx.doi.org/10.13039/501100001713 Women’s Health Project: A HIV prevention trial feasibility study UNSPECIFIED http://dx.doi.org/10.13039/501100000265 Women’s Health Project: A HIV prevention trial feasibility study UNSPECIFIED UNSPECIFIED Women’s Health Project: A HIV prevention trial feasibility study UNSPECIFIED http://dx.doi.org/10.13039/501100000278 |
| Date Deposited | 09 May 2016 11:11 |
| Last Modified | 31 May 2022 10:46 |
| Publisher | London School of Hygiene & Tropical Medicine |
Data / Code
eis_biomarkers.txt
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subject - Data
-
- Available under Creative Commons: Attribution 4.0
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info - Anonymised dataset containing information on sexual behaviour, vaginal practices, current contraception, STI symptoms, as well as results of a clinical and colposcopic examination
description - text/plain
- folder_info
- 177B
Documentation
0111_Codebook.html
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subject - Documentation
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- Available under Creative Commons: Attribution 4.0
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info - Codebook for dataset
html - text/html
- folder_info
- 17kB
0111_Userguide.html
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subject - Documentation
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- Available under Creative Commons: Attribution 4.0
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info - User guide for dataset
html - text/html
- folder_info
- 16kB
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