Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection"
Francis, SC
, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ
(2015).
Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection".
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.104.
, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ
(2015).
Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection".
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.104.
An anonymised dataset containing details of a sub-study of 100 HIV-negative women in 2009. This sub-study was part of a microbicide feasibility study in North-West Tanzania that was carried out between 2008-2010. It contains information on sexual behaviour, vaginal practices, current contraception, STI symptoms, as well as results of a clinical and colposcopic examination
Additional Information
This dataset cannot be made available via a repository due to ethical restrictions. Interested researchers may submit request for de-identified data to Saidi.Kapiga@lshtm.ac.uk.
Keywords
Cytokines; Chemokines; HIV; Microbicides; Vaccines; Sub-Saharan| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Description of data capture | This study was nested within a 12 month microbicide feasibility study of 970 HIV-negative women aged 18–44 years working in bars, hotels, and other food and recreational facilities in the three towns of Geita, Shinyanga and Kahama in northwestern Tanzania from 2008-2010. Participants enrolled in the sub-study were followed up three times a week for 4 weeks (12 visits total). At enrolment, interviews were carried out to obtain information about sexual behaviour, vaginal practices, current contraception, and STI symptoms. On the first and last visit (visits 1 & 12), a clinical and colposcopic examination were performed; cervical and vaginal swabs were collected to test for vaginal pH and reproductive tract infections (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, bacterial vaginosis, and yeast); and a CVL was obtained for the detection of Herpes simplex virus, types 1 and 2 (HSV), prostate-specific antigen (PSA) to measure seminal plasma exposure in the last 48 hours, soluble immune proteins, haemoglobin and white blood cells (WBCs). During visits 2 to 11, a shortened interview was conducted to obtain updated sexual behaviours and intravaginal practices. A brief clinical examination was performed to obtain vaginal swabs for testing vaginal pH, bacterial vaginosis and yeast, and a CVL for the detection of HSV, PSA, soluble immune proteins, haemoglobin and WBCs. Urine was collected at every visit to test for pregnancy and menstrual cycle phase. If a woman was menstruating, no genital samples were obtained on that visit. No blood samples were collected; however laboratory data from the main cohort on HSV antibody status, HIV status and syphilis results were available for the statistical analysis and methods have been reported in a previous study. Colposcopy was carried out by trained clinicians according to the CONRAD/WHO revised manual for the Standardization of Colposcopy for the Evaluation of Vaginal Products |
| Capture method | Interview: Face-to-face, Physical measurements and tests |
| Collection Period |
From To 2008 2010 |
| Date | 24 November 2015 |
| Geographical area covered (offline during plugin upgrade) |
North Latitude East Longitude South Latitude West Longitude -2.8534 32.4068 -2.99853 32.2067 -3.15914 34.3908 -3.57692 33.9139 -3.50223 33.0251 -4.10522 32.3103 |
| Language(s) of written materials | English |
| Creator(s) |
Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ
|
| LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom; St George's, University of London, London, United Kingdom; University of Liverpool, Liverpool, United Kingdom; Imperial College London, London, United Kingdom; National Institute for Medical Research, London, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI Women’s Health Project: A HIV prevention trial feasibility study UNSPECIFIED http://dx.doi.org/10.13039/501100001713 Women’s Health Project: A HIV prevention trial feasibility study UNSPECIFIED http://dx.doi.org/10.13039/501100000265 Women’s Health Project: A HIV prevention trial feasibility study UNSPECIFIED UNSPECIFIED Women’s Health Project: A HIV prevention trial feasibility study UNSPECIFIED http://dx.doi.org/10.13039/501100000278 |
| Date Deposited | 09 May 2016 11:11 |
| Last Modified | 31 May 2022 10:46 |
| Publisher | London School of Hygiene & Tropical Medicine |
Data / Code
eis_biomarkers.txt
-
subject - Data
-
- Available under Creative Commons: Attribution 4.0
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info - Anonymised dataset containing information on sexual behaviour, vaginal practices, current contraception, STI symptoms, as well as results of a clinical and colposcopic examination
description - text/plain
- folder_info
- 177B
Documentation
0111_Codebook.html
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subject - Documentation
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- Available under Creative Commons: Attribution 4.0
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info - Codebook for dataset
html - text/html
- folder_info
- 17kB
0111_Userguide.html
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subject - Documentation
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- Available under Creative Commons: Attribution 4.0
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info - User guide for dataset
html - text/html
- folder_info
- 16kB
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