Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result"

Hanifa, Y, Fielding, K, Grant, AD and Churchyard, GJ. 2016. Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result". [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.284.

Hanifa, Y, Fielding, K, Grant, AD and Churchyard, GJ. Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result". [Internet] LSHTM Data Compass. London, United Kingdom: London School of Hygiene & Tropical Medicine; 2016. Available from: https://doi.org/10.17037/DATA.284.

Hanifa, Y, Fielding, K, Grant, AD and Churchyard, GJ (2016). Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result". [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.284.

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Additional information

Description of data capture A systematic sample of adults attending for HIV care was enrolled to the XPHACTOR study. This substudy was restricted to those at highest risk of tuberculosis (CD4<200 cells/mm3 or unknown) and a negative initial sputum Xpert result. At attendance for the Xpert result, a repeat sputum sample was stored, and further investigations facilitated per national guidelines. Participants were reviewed monthly, with reinvestigation if indicated, for at least three months, when sputum and blood were cultured for mycobacteria, and the stored sputum tested using Xpert. We defined tuberculosis as “confirmed” if Xpert, line probe assay or Mycobacterium tuberculosis culture within six months of enrolment were positive, and “clinical” if tuberculosis treatment was started without microbiological confirmation.
Data capture method Interview: Face-to-face, Questionnaire: Fixed form - Paper
Data Collection Period
FromTo
September 2012March 2014
Date (Completed) August 2016
Geographical area covered
North LatitudeEast LongitudeSouth LatitudeWest Longitude
-25.612428.47-26.348227.8272
Language(s) of written materials English
Data Creators Hanifa, Y, Fielding, K, Grant, AD and Churchyard, GJ
Associated roles Hanifa, Y (Co-Investigator), Fielding, K (Co-Investigator), Chihota, VN (Co-Investigator), Adonis, L (Co-Investigator), Charalambous, S (Co-Investigator), Foster, N (Co-Investigator), Karstaedt, A (Co-Investigator), McCarthy, K (Co-Investigator), Nicol, MP (Co-Investigator), Ndlovu, NT (Project Manager), Sinanovic, E (Co-Investigator), Sahid, F (Other), Stevens, W (Co-Investigator), Vassall, A (Co-Investigator), Churchyard, GJ (Principal Investigator) and Grant, AD (Principal Investigator)
LSHTM Faculty/Department Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre TB Centre
Participating Institutions TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom, The Aurum Institute, South Africa, National Health Laboratory Services, South Africa, University of Cape Town, South Africa
Funders
ProjectFunderGrant NumberFunder URI
Xpert MTB/RIF for people attending HIV care: an interventional cohort study to guide rational implementation (XPHACTOR)UNSPECIFIEDOPP1034523UNSPECIFIED
Depositor Yasmeen Hanifa
Date Deposited 16 Apr 2018 15:33
Last Modified 27 Jul 2018 09:56
Publisher London School of Hygiene & Tropical Medicine

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Filename: XPHACTOR_RepeatXpert_substudy_data.zip

Description: Unlinked Repeat Xpert dataset - MS Excel and CSV format. Data can be reused for HIV and TB related research only

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