Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection"

Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ. 2015. Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection". [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.104.

Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ. Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection". [Internet] LSHTM Data Compass. London, United Kingdom: London School of Hygiene & Tropical Medicine; 2015. Available from: https://doi.org/10.17037/DATA.104.

Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ (2015). Data for: "Immune activation in the female genital tract: Expression profiles of soluble proteins in women at high risk for HIV infection". [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.104.

Description

Description of data capture This study was nested within a 12 month microbicide feasibility study of 970 HIV-negative women aged 18–44 years working in bars, hotels, and other food and recreational facilities in the three towns of Geita, Shinyanga and Kahama in northwestern Tanzania from 2008-2010. Participants enrolled in the sub-study were followed up three times a week for 4 weeks (12 visits total). At enrolment, interviews were carried out to obtain information about sexual behaviour, vaginal practices, current contraception, and STI symptoms. On the first and last visit (visits 1 & 12), a clinical and colposcopic examination were performed; cervical and vaginal swabs were collected to test for vaginal pH and reproductive tract infections (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, bacterial vaginosis, and yeast); and a CVL was obtained for the detection of Herpes simplex virus, types 1 and 2 (HSV), prostate-specific antigen (PSA) to measure seminal plasma exposure in the last 48 hours, soluble immune proteins, haemoglobin and white blood cells (WBCs). During visits 2 to 11, a shortened interview was conducted to obtain updated sexual behaviours and intravaginal practices. A brief clinical examination was performed to obtain vaginal swabs for testing vaginal pH, bacterial vaginosis and yeast, and a CVL for the detection of HSV, PSA, soluble immune proteins, haemoglobin and WBCs. Urine was collected at every visit to test for pregnancy and menstrual cycle phase. If a woman was menstruating, no genital samples were obtained on that visit. No blood samples were collected; however laboratory data from the main cohort on HSV antibody status, HIV status and syphilis results were available for the statistical analysis and methods have been reported in a previous study. Colposcopy was carried out by trained clinicians according to the CONRAD/WHO revised manual for the Standardization of Colposcopy for the Evaluation of Vaginal Products
Data capture method Interview: Face-to-face, Physical measurements and tests
Data Collection Period
FromTo
20082010
Date (Completed) 24 November 2015
Geographical area covered
North LatitudeEast LongitudeSouth LatitudeWest Longitude
-2.853432.276-2.9114432.2067
-3.2359234.3256-3.5296333.9881
-3.5022332.8878-4.0586532.3103
Language(s) of written materials English
Data Creators Francis, SC, Hou, Y, Baisley, K, Van de wijgert, J, Watson-Jones, D, Ao, TT, Herrera, C, Maganja, K, Andreasen, A, Coulton, GR, Hayes, RJ and Shattock, RJ
LSHTM Faculty/Department Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Participating Institutions London School of Hygiene & Tropical Medicine, St George's, University of London, University of Liverpool, Imperial College London, National Institute for Medical Research
Funders
ProjectFunderGrant NumberFunder URI
Women’s Health Project: A HIV prevention trial feasibility studyEuropean and Developing Countries Clinical Trials PartnershipUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDMedical Research CouncilUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDInternational Partnership For MicrobicidesUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDDepartment for International DevelopmentUNSPECIFIEDUNSPECIFIED
Depositor Suzanna Francis
Date Deposited 09 May 2016 11:11
Last Modified 09 May 2016 12:11
Publisher London School of Hygiene & Tropical Medicine

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