Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis
Claessens, A, Hamilton, WL, Kekre, M, Otto, TD, Faizullabhoy, A, Rayner, JC and Kwiatkowski, D
(2014).
Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis.
[Dataset].
PLOS Genetics.
https://doi.org/10.1371/journal.pmed.1001893p://dx.doi.org/10.1371/journal.pmed.1001893
Supplementary data for PLOS Genetics paper on the creation of antigenic diversity in Plasmodium falciparum through structured rearrangement of Var genes during mitosis.
Keywords
Genome sequence analysis, Plasmodium falciparum, Polymorphic gene family, Falciparum erythrocyte membrane protein, Var gene sequence, Var exon, Nucleotide sequence identityData / Code
S1_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - Genome coverage for each subclone
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
- folder_info
- 70kB
S2_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - SNPs identified in clone trees
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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- 69kB
S3_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - Structural variants identified in the 3D7 clone tree, represented in Fig. 1
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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- 141kB
S4_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - All var gene recombinations
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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- 96kB
S5_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - Mitotic point mutation rates and var gene recombination rates measured from clone trees
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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- 55kB
S6_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - Primers used for validating point mutations and var gene recombination by PCR amplification and capillary sequencing
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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- 11kB
S7_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - Crosses progeny culture time and var gene recombinations
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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- 38kB
Data Visualisation
S1_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Generating clone trees
picture_as_pdf - application/pdf
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- 782kB
S2_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Chimeric var gene created by recombination
picture_as_pdf - application/pdf
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- 336kB
S3_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Example of 7 recombination events within var gene exon2 in 3D7_1b
picture_as_pdf - application/pdf
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- 967kB
S4_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Triple recombination event within less than 50 bp
picture_as_pdf - application/pdf
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- 323kB
S5_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Duplications in internal var gene clusters can also generate chimeras
picture_as_pdf - application/pdf
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- 703kB
S6_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Another example of internal var gene clusters generating chimeras
picture_as_pdf - application/pdf
- folder_info
- 602kB
S7_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Evolution of a var gene
picture_as_pdf - application/pdf
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- 583kB
S10_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Defining identity blocks. Var B/C genes recombine (A) ClustalW alignment of Dd2var34 and Dd2var45 at a crossover
picture_as_pdf - application/pdf
- folder_info
- 186kB
S13_Fig.eps
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Distribution of var exon 1 recombination within each domain class
description - application/postscript
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- 469kB
S14_Fig.eps
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - No recombination hotspot within DBL domains
description - application/postscript
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- 181kB
S15_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - No conserved motifs within Identity Blocks.
picture_as_pdf - application/pdf
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- 173kB
S8_Fig.png
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - All var exon 1 translocations identified in this study
image - image/png
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- 4MB
S9_Fig.png
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Group B/C var genes do not necessarily recombine with var genes of highest similarity
image - image/png
- folder_info
- 2MB
S11_Fig.png
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Recombination in var genes occurs where sequences are similar
image - image/png
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- 1MB
S12_Fig.png
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Var gene exon 1 recombine in short regions of higher homology
image - image/png
- folder_info
- 4MB
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