Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis
Claessens, A, Hamilton, WL, Kekre, M, Otto, TD, Faizullabhoy, A, Rayner, JC and Kwiatkowski, D
(2014).
Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis.
[Dataset].
PLOS Genetics.
https://doi.org/10.1371/journal.pmed.1001893p://dx.doi.org/10.1371/journal.pmed.1001893
Supplementary data for PLOS Genetics paper on the creation of antigenic diversity in Plasmodium falciparum through structured rearrangement of Var genes during mitosis.
Keywords
Genome sequence analysis; Plasmodium falciparum; Polymorphic gene family; Falciparum erythrocyte membrane protein; Var gene sequence; Var exon; Nucleotide sequence identityData / Code
S1_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - Genome coverage for each subclone
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
- folder_info
- 70kB
S2_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - SNPs identified in clone trees
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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- 69kB
S3_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - Structural variants identified in the 3D7 clone tree, represented in Fig. 1
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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- 141kB
S4_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - All var gene recombinations
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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- 96kB
S5_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - Mitotic point mutation rates and var gene recombination rates measured from clone trees
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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- 55kB
S6_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - Primers used for validating point mutations and var gene recombination by PCR amplification and capillary sequencing
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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- 11kB
S7_Table.xlsx
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subject - Data
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- Available under Creative Commons: Attribution 3.0
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info - Crosses progeny culture time and var gene recombinations
grid_on - application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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- 38kB
Data Visualisation
S1_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Generating clone trees
picture_as_pdf - application/pdf
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- 782kB
S2_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Chimeric var gene created by recombination
picture_as_pdf - application/pdf
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- 336kB
S3_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Example of 7 recombination events within var gene exon2 in 3D7_1b
picture_as_pdf - application/pdf
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- 967kB
S4_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Triple recombination event within less than 50 bp
picture_as_pdf - application/pdf
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- 323kB
S5_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Duplications in internal var gene clusters can also generate chimeras
picture_as_pdf - application/pdf
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- 703kB
S6_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Another example of internal var gene clusters generating chimeras
picture_as_pdf - application/pdf
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- 602kB
S7_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Evolution of a var gene
picture_as_pdf - application/pdf
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- 583kB
S10_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Defining identity blocks. Var B/C genes recombine (A) ClustalW alignment of Dd2var34 and Dd2var45 at a crossover
picture_as_pdf - application/pdf
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- 186kB
S13_Fig.eps
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Distribution of var exon 1 recombination within each domain class
description - application/postscript
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- 469kB
S14_Fig.eps
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - No recombination hotspot within DBL domains
description - application/postscript
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- 181kB
S15_Fig.pdf
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - No conserved motifs within Identity Blocks.
picture_as_pdf - application/pdf
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- 173kB
S8_Fig.png
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - All var exon 1 translocations identified in this study
image - image/png
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- 4MB
S9_Fig.png
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Group B/C var genes do not necessarily recombine with var genes of highest similarity
image - image/png
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- 2MB
S11_Fig.png
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Recombination in var genes occurs where sequences are similar
image - image/png
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- 1MB
S12_Fig.png
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subject - Graphical representation of data
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- Available under Creative Commons: Attribution 3.0
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info - Var gene exon 1 recombine in short regions of higher homology
image - image/png
- folder_info
- 4MB
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