Data on pharmacokinetics of praziquantel and inflammatory markers in preschool age children from Albertine Region of Western Uganda treated for Schistosoma mansoni
Edielu, A
; Obura, B; Mawa, PA; Holland, MJ; Webb, EL; Elliott, AM; Barry, M; Mancini, N; Fischer, FC; Colt, S; Friedman, JF; Hope, W; Waitt, C and Bustinduy, AL
(2026).
Data on pharmacokinetics of praziquantel and inflammatory markers in preschool age children from Albertine Region of Western Uganda treated for Schistosoma mansoni.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00005306.
; Obura, B; Mawa, PA; Holland, MJ; Webb, EL; Elliott, AM; Barry, M; Mancini, N; Fischer, FC; Colt, S; Friedman, JF; Hope, W; Waitt, C and Bustinduy, AL
(2026).
Data on pharmacokinetics of praziquantel and inflammatory markers in preschool age children from Albertine Region of Western Uganda treated for Schistosoma mansoni.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00005306.
Anonymized dataset of 184 preschool age children (PSAC) treated for Schistosoma mansoni from Albertine Region of Western Uganda. Participants were recruited between April 2021 and February 2023. Dataset includes demographic variables, schistosomiasis infection parameters, anthropometric data, praziquantel pharmacokinetic variables as well as intestinal and systemic inflammatory markers.
Alternative Title
Praziquantel pharmacokinetic parameters and inflammatory markers in Schistosoma mansoni infection
Keywords
Schistosomiasis; Environmental Enteric Dysfunction; Inflammation; Praziquantel; Pharmacokinetics| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Description of data capture | Demographic data was obtained through completion of interview questionnaires. Anthropometric measurements (weight and height) yielded primary data that was used to calculate height-for-age z-scores, weight-for-age z-scores and weight-for-height z-scores. Intestinal and systemic markers were obtained from stool, urine and plasma samples through Enzyme-Linked Immunosorbent Assay (ELISA) and High-Pressure Liquid Chromatography (HPLC). Plasma praziquantel was quantified using ultra-high performance liquid chromatography mass spectrometry from which Area Under the Curve (AUC), maximum concentration (Cmax) and time to maximum concentration (Tmax) were calculated. Data cleaning was done in REDCap database where the initial entry was made and exported to STATA 19 for analysis. Descriptive analysis was done followed by crude and adjusted regression models to assess association between schistosomiasis infection status and inflammatory markers. |
| Capture method | Interview: Face-to-face, Questionnaire, Measurements and tests |
| Collection Period |
From To April 2021 February 2023 |
| Date | 9 July 2026 |
| Language(s) of written materials | English |
| Creator(s) |
Edielu, A; Obura, B; Mawa, PA; Holland, MJ; Webb, EL; Elliott, AM; Barry, M; Mancini, N; Fischer, FC; Colt, S; Friedman, JF; Hope, W; Waitt, C and Bustinduy, AL
|
| LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology & International Health (2023-) Faculty of Infectious and Tropical Diseases > Dept of Clinical Research MRC/UVRI and LSHTM Uganda Research Unit |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI Praziquantel pharmacokinetic data from Praziquantel for children under age four years: A Phase II PK/PD driven dose finding trial (PIP trial) R01 HD095562 https://doi.org/10.13039/100000002 Praziquantel pharmacokinetic data from Praziquantel for children under age four years: A Phase II PK/PD driven dose finding trial (PIP trial) R01 HD095562 https://doi.org/10.13039/100000071 |
| Date Deposited | 09 Jul 2026 13:48 |
| Last Modified | 09 Jul 2026 13:48 |
| Publisher | London School of Hygiene & Tropical Medicine |
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Data / Code
Prazi_PK_and_EED_dataset.csv
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subject - Data
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- Available under Creative Commons: Attribution 4.0
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info - Dataset on praziquantel pharmacokinetics and inflammatory markers
grid_on - text/csv
- folder_info
- 32kB
Documentation
Prazi_PK_and_EED_dataset_codebook.html
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subject - Documentation
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- Available under Creative Commons: Attribution 4.0
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info - Code book for the dataset
html - text/html
- folder_info
- 9kB
5306_UserGuide.html
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subject - Documentation
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- Available under Creative Commons: Attribution 4.0
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info - User guide for the dataset
html - text/html
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- 8kB
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