10.17037/DATA.00005306
Anonymized dataset of 184 preschool age children (PSAC) treated for Schistosoma mansoni from Albertine Region of Western Uganda. Participants were recruited between April 2021 and February 2023. Dataset includes demographic variables, schistosomiasis infection parameters, anthropometric data, praziquantel pharmacokinetic variables as well as intestinal and systemic inflammatory markers.
The following variables are contained within the dataset.
| Variable Name | Variable Label | Answer Label | Answer Code | Variable Type |
| ID | Participant ID (unlinked) | Open ended | Numeric | |
| Age | Participant age (in completed years) | Open ended | Numeric | |
| Sex | Participant sex | |||
| Female | 1 | |||
| Male | 2 | |||
| epg | Schistosome eggs per gram of stool | Open ended | Numeric | |
| caa | Circulating Anodic Antigen (pg/ml) | Open ended | Numeric | |
| calprotectin | Calprotectin (µg/mL) | Open ended | Integer | |
| fob | Presence of Faecal Ocult Blood | String | ||
| No | 0 | |||
| Yes | 1 | |||
| ifabp | Intestinal Fatty Acid Binding Protein (pg/mL) | Open ended | Numeric | |
| endocab | Endotoxin core Antibody (GMU/mL) | Open ended | Numeric | |
| lmratio | Lactulose-Mannitol Ratio | Open ended | Numeric | |
| aat | Alpha-1 Antitrypsin (µg/mL) | Open ended | Numeric | |
| tmax | Time to maximum concentration (hours) | Open ended | Numeric | |
| cmax | Maximum concentration (mg) | Open ended | Numeric | |
| dose | PZQ dose received (mg) | Open ended | Integer | |
| auc | Area Under the Curve (microgram.h/mL) | Open ended | Numeric | |
| dose4080 | Praziquantel dose (mg/kg) | |||
| 40 mg/kg | 40 | |||
| 80 mg/kg | 80 | |||
| TmaxMins2 | Time to maximum concentration (minutes) | Open ended | Numeric | |
| EPGcat | Schistosomiasis infection categories | Numeric | ||
| Light Infection | 1 | |||
| Moderate Infection | 2 | |||
| Heavy Infection | 3 | |||
| CRPclean | C-reactive protein (mg/L) | Open ended | Numeric | |
| AUClog | Log Area Under the Curve | Open ended | Numeric | |
| cmaxlog | Log Maximum concentration | Open ended | Numeric | |
| IFABPlog | Log Intestinal Fatty Acid Binding Protein | Open ended | Numeric | |
| CalpLog | Log Calprotectin | Open ended | Numeric | |
| EndoCABLog | Log Endotoxin core Antibody | Open ended | Numeric | |
| LMlog | Log Lactulose-Mannitol Ratio | Open ended | Numeric | |
| AATlog | Log Alpha-1 Antitrypsin | Open ended | Numeric | |
| CRPlog | Log C-reactive protein | Open ended | Numeric | |
| R_Cmax | Maximum concentration of R-praziquantel (mg/L) | Open ended | Numeric | |
| R_Tmax | Time to maximum concentration of R-praziquantel (hours) | Open ended | Numeric | |
| R_AUClast | Last quantifiable AUC of R-praziquantel (mg·h/L) | Open ended | Numeric | |
| R_AUCinf | Cumulative expsure until total elimination (mg·h/L) | Open ended | Numeric | |
| R_ke_ind | Rate elimination constant for R-praziquantel (1/h) | Open ended | Numeric | |
| S_Cmax | Maximum concentration of S-praziquantel (mg/L) | Open ended | Numeric | |
| S_Tmax | Time to maximum concentration of S-praziquantel (hours) | Open ended | Numeric | |
| S_AUClast | Last quantifiable AUC of S-praziquantel (mg·h/L) | Open ended | Numeric | |
| S_AUCinf | Cumulative exposure until total elimination of S-praziquantel (mg·h/L) | Open ended | Numeric | |
| S_ke_ind | Rate elimination constant for S-praziquantel (1/h) | Open ended | Numeric | |
| RS_Cmax | R-/S-PZQ maximum concentration | Open ended | Numeric | |
| RS_AUClast | R-/S-PZQ last quantifiable AUC | Open ended | Numeric | |
| RS_AUCinf | R-/S-PZQ cumulative exposure until total elimination | Open ended | Numeric | |
| comb_k | Combined rate elimination constant (1/h) | Open ended | Numeric | |
| comb_thalf | Combined half-life (h) | Open ended | Numeric | |
| ka_estimated | Estimated rate elimination cosntant (1/h) | Open ended | Numeric | |
| ka_type | Nature of rate elimination constant | Numeric | ||
| conventional | 1 | |||
| flip-flop | 2 | |||
| ka_reliability | reliability of rate elimination constant | Numeric | ||
| reliable | 1 | |||
| unreliable (Tmax ≤ 1.5 h) | 2 | |||
| t_abs_half | Absorption half-life | Open ended | Numeric |