Data for: "Effect of malaria intermittent preventive treatment on SARS-CoV-2 seroprevalence and response to COVID-19 vaccination: longitudinal study nested within a randomised controlled trial"
; Nassuuna, J; Nayebare, D; Baine, C; Namutebi, M; Zziwa, C; Nsubuga, D; Oduru, G; Akello-Ateng, F; Ninsiima, C; Mutebe, A; Wajja, A; Kimuda, S; Natukunda, A; Nkurunungi, G; Serwanga, J; Elliott, A and Webb, E
(2026).
Data for: "Effect of malaria intermittent preventive treatment on SARS-CoV-2 seroprevalence and response to COVID-19 vaccination: longitudinal study nested within a randomised controlled trial".
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00005133.
This dataset contains longitudinal serological data from a study nested within the POPVAC B randomised, double-blind, placebo-controlled trial conducted among school-aged children in Uganda. It includes participant demographics, malaria infection status, and SARS-CoV-2 antibody measurements (spike and nucleocapsid IgG) collected at multiple timepoints before and after COVID-19 vaccination. Data capture exposure to intermittent preventive treatment with dihydroartemisinin–piperaquine or placebo, as well as COVID-19 vaccination status and timing. The dataset supports analyses of SARS-CoV-2 seroprevalence, antibody responses, and fold changes in relation to malaria chemoprevention and vaccination in a malaria-endemic setting.
Additional Information
Data access is restricted due to ethical conditions associated with the original study. Data will be made available for use in ethically-approved research, subject to a Data Transfer Agreement being arranged with the MRC/UVRI and LSHTM Uganda Research Unit. Applications are assessed by the PI (Professor Alison Elliott) with the POPVAC investigator team, in consultation with the POPVAC steering committee.
Keywords
Malaria; SARS-CoV-2; COVID-19 vaccination; Uganda| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Questionnaire, Experiment: Laboratory |
| Collection Period |
From To 25 May 2021 6 September 2022 |
| Date | 30 March 2026 |
| Geographical area covered (offline during plugin upgrade) |
North East South West 0.7 33.3 0.3 32.8 |
| Language(s) of written materials | English |
| Creator(s) |
Zirimenya, L; Nassuuna, J; Nayebare, D; Baine, C; Namutebi, M; Zziwa, C; Nsubuga, D; Oduru, G; Akello-Ateng, F; Ninsiima, C; Mutebe, A; Wajja, A; Kimuda, S; Natukunda, A; Nkurunungi, G; Serwanga, J; Elliott, A and Webb, E
|
| LSHTM Faculty/Department |
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research MRC/UVRI and LSHTM Uganda Research Unit |
| Research Centre |
Malaria Centre Vaccine Centre |
| Research Group | Immunomodulation and Vaccines Group |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom; MRC/UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda |
| Funders |
Project Funder Grant Number Funder URI VAnguard NIHR134531 https://doi.org/10.13039/501100000272 |
| Date Deposited | 31 Mar 2026 09:30 |
| Last Modified | 31 Mar 2026 09:51 |
| Publisher | London School of Hygiene & Tropical Medicine |
Explore Further
- Zirimenya, Ludoviko
- Nayebare, Doreen
- Baine, Claire
- Namutebi, Milly
- Zziwa, Christopher
- Nsubuga, Denis
- Oduru, Gloria
- Ninsiima, Caroline
- Mutebe, Alex
- Wajja, Anne
- Natukunda, Agnes
- Nkurunungi, Gyaviira
- Serwanga, Jennifer
- Elliott, Alison
- Webb, Emily
Data / Code
-
subject - Data
-
lock - Restricted to Request access for all
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copyright - Available under Data Sharing Agreement
-
info - SARS-CoV-2 POPVAC B dataset
description - text/plain
- folder_info
- 62B
Documentation
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subject - Documentation
-
- Available under Creative Commons: Attribution 4.0
-
info - Codebook for SARS-CoV-2 POPVAC B dataset
html - text/html
- folder_info
- 32kB
