Data for: "Effect of malaria intermittent preventive treatment on SARS-CoV-2 seroprevalence and response to COVID-19 vaccination: longitudinal study nested within a randomised controlled trial" – Data codebook

Persistent identifier

10.17037/DATA.00005133

Description

This dataset contains longitudinal serological data from a study nested within the POPVAC B randomised, double-blind, placebo-controlled trial conducted among school-aged children in Uganda. It includes participant demographics, malaria infection status, and SARS-CoV-2 antibody measurements (spike and nucleocapsid IgG) collected at multiple timepoints before and after COVID-19 vaccination. Data capture exposure to intermittent preventive treatment with dihydroartemisinin–piperaquine or placebo, as well as COVID-19 vaccination status and timing. The dataset supports analyses of SARS-CoV-2 seroprevalence, antibody responses, and fold changes in relation to malaria chemoprevention and vaccination in a malaria-endemic setting.

Codebook

The dataset contains the 93 variables outlined below.

Variable Name Variable Label Answer Label Answer Code Variable Type
sex_b Participant sex     Numeric
    Male 1  
    Female 2  
age_b Participant age (in years) Open ended   Numeric
schnm_b School ID     Numeric
    School 1 1  
    School 2 2  
    School 3 3  
    School 4 4  
    School 5 5  
    School 6 6  
    School 7 7  
    School 8 8  
bcgscar_b BCG scar     Numeric
    absent 0  
    present 1  
    uncertain 98  
trialarm_b Trial arm     Numeric
    Placebo 0  
    DP 1  
covid_vaccinated_b Have you been vaccinated for covid     Numeric
    No 0  
    Yes 1  
h_doses_b Highest dose of covid vaccination Open ended   Numeric
dpd1_wpre6_b dp/placebo dose 1 admin 6 weeks before BCG     Numeric
    No 0  
    Yes 1  
dpd2_wpre6_b dp/placebo dose 2 admin 6 weeks before BCG     Numeric
    No 0  
    Yes 1  
dpd3_wpre6_b dp/placebo dose 3 admin 6 weeks before BCG     Numeric
    No 0  
    Yes 1  
dpd1_wpre2_b dp/placebo dose 1 admin 2 weeks before BCG     Numeric
    No 0  
    Yes 1  
dpd2_wpre2_b dp/placebo dose 2 admin 2 weeks before BCG     Numeric
    No 0  
    Yes 1  
dpd3_wpre2_b dp/placebo dose 3 admin 2 weeks before BCG     Numeric
    No 0  
    Yes 1  
dpd1_w2_b dp/placebo dose 1 admin week 2     Numeric
    No 0  
    Yes 1  
dpd2_w2_b dp/placebo dose 2 admin week 2     Numeric
    No 0  
    Yes 1  
dpd3_w2_b dp/placebo dose 3 admin week 2     Numeric
    No 0  
    Yes 1  
dpd1_w6_b dp/placebo dose 1 admin week 6     Numeric
    No 0  
    Yes 1  
dpd2_w6_b dp/placebo dose 2 admin week 6     Numeric
    No 0  
    Yes 1  
dpd3_w6_b dp/placebo dose 3 admin week 6     Numeric
    No 0  
    Yes 1  
dpd1_w10_b dp/placebo dose 1 admin week 10     Numeric
    No 0  
    Yes 1  
dpd2_w10_b dp/placebo dose 2 admin week 10     Numeric
    No 0  
    Yes 1  
dpd3_w10_b dp/placebo dose 3 admin week 10     Numeric
    No 0  
    Yes 1  
dpd1_w14_b dp/placebo dose 1 admin week 14     Numeric
    No 0  
    Yes 1  
dpd2_w14_b dp/placebo dose 2 admin week 14     Numeric
    No 0  
    Yes 1  
dpd3_w14_b dp/placebo dose 3 admin week 14     Numeric
    No 0  
    Yes 1  
dpd1_w18_b dp/placebo dose 1 admin week 18     Numeric
    No 0  
    Yes 1  
dpd2_w18_b dp/placebo dose 2 admin week 18     Numeric
    No 0  
    Yes 1  
dpd3_w18_b dp/placebo dose 3 admin week 18     Numeric
    No 0  
    Yes 1  
dpd1_w22_b dp/placebo dose 1 admin week 22     Numeric
    No 0  
    Yes 1  
dpd2_w22_b dp/placebo dose 2 admin week 22     Numeric
    No 0  
    Yes 1  
dpd3_w22_b dp/placebo dose 3 admin week 22     Numeric
    No 0  
    Yes 1  
dpd1_w26_b dp/placebo dose 1 admin week 26     Numeric
    No 0  
    Yes 1  
dpd2_w26_b dp/placebo dose 2 admin week 26     Numeric
    No 0  
    Yes 1  
dpd3_w26_b dp/placebo dose 3 admin week 26     Numeric
    No 0  
    Yes 1  
dpd1_w30_b dp/placebo dose 1 admin week 30     Numeric
    No 0  
    Yes 1  
dpd2_w30_b dp/placebo dose 2 admin week 30     Numeric
    No 0  
    Yes 1  
dpd3_w30_b dp/placebo dose 3 admin week 30     Numeric
    No 0  
    Yes 1  
dpd1_w34_b dp/placebo dose 1 admin week 34     Numeric
    No 0  
    Yes 1  
dpd2_w34_b dp/placebo dose 2 admin week 34     Numeric
    No 0  
    Yes 1  
dpd3_w34_b dp/placebo dose 3 admin week 34     Numeric
    No 0  
    Yes 1  
dpd1_w38_b dp/placebo dose 1 admin week 38     Numeric
    No 0  
    Yes 1  
dpd2_w38_b dp/placebo dose 2 admin week 38     Numeric
    No 0  
    Yes 1  
dpd3_w38_b dp/placebo dose 3 admin week 38     Numeric
    No 0  
    Yes 1  
dpd1_w42_b dp/placebo dose 1 admin week 42     Numeric
    No 0  
    Yes 1  
dpd2_w42_b dp/placebo dose 2 admin week 42     Numeric
    No 0  
    Yes 1  
dpd3_w42_b dp/placebo dose 3 admin week 42     Numeric
    No 0  
    Yes 1  
dpd1_w46_b dp/placebo dose 1 admin week 46     Numeric
    No 0  
    Yes 1  
dpd2_w46_b dp/placebo dose 2 admin week 46     Numeric
    No 0  
    Yes 1  
dpd3_w46_b dp/placebo dose 3 admin week 46     Numeric
    No 0  
    Yes 1  
dpd1_w50_b dp/placebo dose 1 admin week 50     Numeric
    No 0  
    Yes 1  
dpd2_w50_b dp/placebo dose 2 admin week 50     Numeric
    No 0  
    Yes 1  
dpd3_w50_b dp/placebo dose 3 admin week 50     Numeric
    No 0  
    Yes 1  
pzq_w8_b pzq admin week 8     Numeric
    No 0  
    Yes 1  
alb_w8_b Albendazole admin week 8     Numeric
    No 0  
    Yes 1  
alb_w28_b Albendazole admin week 28     Numeric
    No 0  
    Yes 1  
completed_b Participant completed study     Numeric
    No 0  
    Yes 1  
pfal_res_screen_b P. falciparum PCR result, screening timepoint     String
    Negative 0  
    Positive 1  
pfal_res_wk0_b P. falciparum PCR result, week 0 timepoint     String
    Negative 0  
    Positive 1  
pfal_res_wk4_b P. falciparum PCR result, week 4 timepoint     String
    Negative 0  
    Positive 1  
pfal_res_wk8_b P. falciparum PCR result, week 8 timepoint     String
    Negative 0  
    Positive 1  
pfal_res_wk28_b P. falciparum PCR result, week 28 timepoint     String
    Negative 0  
    Positive 1  
pfal_res_wk52_b P. falciparum PCR result, week 52 timepoint     String
    Negative 0  
    Positive 1  
sm_screening_caa_pcr_b Schistosoma Mansoni Circulating Anodic Antigen and PCR results at baseline     Numeric
    Negative 0  
    Positive 1  
bmi_b Body Mass Index Open ended   Numeric
Sconc_wk0 POPVAC B wk0 IgG, S protein, Arbitrary ELISA Units (AEU) Open ended   Numeric
Nconc_wk0 POPVAC B wk0 IgG, N protein, AEU Open ended   Numeric
Sconc_wk4 POPVAC B wk4 IgG, S protein, AEU Open ended   Numeric
Nconc_wk4 POPVAC B wk4 IgG, N protein, AEU Open ended   Numeric
Sconc_wk8 POPVAC B wk8 IgG, S protein, AEU Open ended   Numeric
Nconc_wk8 POPVAC B wk8 IgG, N protein, AEU Open ended   Numeric
Sconc_wk52 POPVAC B wk52 IgG, S protein, AEU Open ended   Numeric
Nconc_wk52 POPVAC B wk52 IgG, N protein, AEU Open ended   Numeric
moccupation_category1 Mother's occupation     Numeric
    Employed 1  
    Unemployed 2  
    Housewives 3  
    Died/Don't Know 4  
post_bin_Sconc_wk0 S-Antibody Seroposivity at week 0     Numeric
    Negative 0  
    Positive 1  
    Not recorded -  
post_bin_Sconc_wk4 S-Antibody Seroposivity at week 4     Numeric
    Negative 0  
    Positive 1  
    Not recorded -  
post_bin_Sconc_wk8 S-Antibody Seroposivity at week 8     Numeric
    Negative 0  
    Positive 1  
    Not recorded -  
post_bin_Sconc_wk52 S-Antibody Seroposivity at week 52     Numeric
    Negative 0  
    Positive 1  
    Not recorded -  
post_bin_Nconc_wk0 N-Antibody Seroposivity at week 0     Numeric
    Negative 0  
    Positive 1  
    Not recorded -  
post_bin_Nconc_wk4 N-Antibody Seroposivity at week 4     Numeric
    Negative 0  
    Positive 1  
    Not recorded -  
post_bin_Nconc_wk8 N-Antibody Seroposivity at week 8     Numeric
    Negative 0  
    Positive 1  
    Not recorded -  
post_bin_Nconc_wk52 N-Antibody Seroposivity at week 52     Numeric
    Negative 0  
    Positive 1  
    Not recorded -  
seropositive_status_wk0 S- and N-Antibody combined Seroposivity at week 0     Numeric
    Not Infected 0  
    Infected 1  
seropositive_status_wk4 S- and N-Antibody combined Seroposivity at week 4     Numeric
    Not Infected 0  
    Infected 1  
seropositive_status_wk8 S- and N-Antibody combined Seroposivity at week 8     Numeric
    Not Infected 0  
    Infected 1  
seropositive_status_wk52 S- and N-Antibody combined Seroposivity at week 52     Numeric
    Not Infected 0  
    Infected 1  
log_Sconc_wk0 SARS-CoV-2 log S-antibody levels at week 0 Open ended   Numeric
log_Sconc_wk4 SARS-CoV-2 log S-antibody levels at week 4 Open ended   Numeric
log_Sconc_wk8 SARS-CoV-2 log S-antibody levels at week 8 Open ended   Numeric
log_Sconc_wk52 SARS-CoV-2 log S-antibody levels at week 52 Open ended   Numeric
log_Nconc_wk0 SARS-CoV-2 log N-antibody levels at week 0 Open ended   Numeric
log_Nconc_wk4 SARS-CoV-2 log N-antibody levels at week 4 Open ended   Numeric
log_Nconc_wk8 SARS-CoV-2 log N-antibody levels at week 8 Open ended   Numeric
log_Nconc_wk52 SARS-CoV-2 log N-antibody levels at week 52 Open ended   Numeric