A protocol for emulating four published randomised controlled trials using registry data: effects of antibiotics in cystic fibrosis

Granger, E, Allen, L, Charman, S, Clarke, S, Davies, G, Frost, F, Plowman, H, Tomlinson, LA and Keogh, R. 2025. A protocol for emulating four published randomised controlled trials using registry data: effects of antibiotics in cystic fibrosis. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/PUBS.00004647.

Granger, E, Allen, L, Charman, S, Clarke, S, Davies, G, Frost, F, Plowman, H, Tomlinson, LA and Keogh, R. A protocol for emulating four published randomised controlled trials using registry data: effects of antibiotics in cystic fibrosis [Internet]. London School of Hygiene & Tropical Medicine; 2025. Available from: https://doi.org/10.17037/PUBS.00004647.

Granger, E, Allen, L, Charman, S, Clarke, S, Davies, G, Frost, F, Plowman, H, Tomlinson, LA and Keogh, R (2025). A protocol for emulating four published randomised controlled trials using registry data: effects of antibiotics in cystic fibrosis. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/PUBS.00004647.

Description

This projects aims to: (1) establish best practices for application of target trial emulation methodology using UK CF Registry data to estimate effects of treatments in cystic fibrosis. (2) apply the methods to emulate four existing RCTs that have been conducted assessing the effects of antibiotics. (3) extend Aim 2 to questions that have not yet been studied in RCTs, including to estimate longer-term effects of antibiotics and the effects in CFTR modulator users.

Methods

Data capture method	Other
Date (Date submitted to LSHTM repository)	8 April 2025
Language(s) of written materials	English

People & Groups

Data Creators	Granger, E, Allen, L, Charman, S, Clarke, S, Davies, G, Frost, F, Plowman, H, Tomlinson, LA and Keogh, R
Associated roles	Granger, E (Project Leader) and Keogh, R (Project Leader)
LSHTM Faculty/Department	Faculty of Epidemiology and Population Health > Dept of Medical Statistics Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom, Cystic Fibrosis Trust, UCL Great Ormond Street Institute of Child Health, London, United Kingdom, University of Liverpool, Liverpool, United Kingdom

Projects

Funders

Project	Funder	Grant Number	Funder URI
Target trial emulation in cystic fibrosis: optimising methods for evaluating antibiotic treatment using registry data	National Institute for Health and Care Research	NIHR206915	https://doi.org/10.13039/501100000272