A protocol for emulating four published randomised controlled trials using registry data: effects of antibiotics in cystic fibrosis
Granger, E
, Allen, L, Charman, S, Clarke, S, Davies, G, Frost, F, Plowman, H, Tomlinson, LA and Keogh, R
(2025).
A protocol for emulating four published randomised controlled trials using registry data: effects of antibiotics in cystic fibrosis.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/PUBS.00004647.
, Allen, L, Charman, S, Clarke, S, Davies, G, Frost, F, Plowman, H, Tomlinson, LA and Keogh, R
(2025).
A protocol for emulating four published randomised controlled trials using registry data: effects of antibiotics in cystic fibrosis.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/PUBS.00004647.
This projects aims to: (1) establish best practices for application of target trial emulation methodology using UK CF Registry data to estimate effects of treatments in cystic fibrosis. (2) apply the methods to emulate four existing RCTs that have been conducted assessing the effects of antibiotics. (3) extend Aim 2 to questions that have not yet been studied in RCTs, including to estimate longer-term
effects of antibiotics and the effects in CFTR modulator users.
Keywords
cystic fibrosis, observational study, registries, target trial emulation| Item Type | Dataset |
|---|---|
| Capture method | Other |
| Date | 8 April 2025 |
| Language(s) of written materials | English |
| Creator(s) |
Granger, E, Allen, L, Charman, S, Clarke, S, Davies, G, Frost, F, Plowman, H, Tomlinson, LA and Keogh, R
|
| Associated roles | Granger, E (Project Leader) and Keogh, R (Project Leader) |
| LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Medical Statistics Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom, Cystic Fibrosis Trust, UCL Great Ormond Street Institute of Child Health, London, United Kingdom, University of Liverpool, Liverpool, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI Target trial emulation in cystic fibrosis: optimising methods for evaluating antibiotic treatment using registry data NIHR206915 https://doi.org/10.13039/501100000272 |
| Date Deposited | 08 Apr 2025 17:18 |
| Last Modified | 08 Apr 2025 17:58 |
| Publisher | London School of Hygiene & Tropical Medicine |
Protocol_TTE_Benchmarking_trials_in_CF.docx
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