Plasma biomarker data from the FIEBRE-Mozambique Cohort

Balanza, N, Bassat, Q, Kain, KC, Hopkins, H, Mabey, DC and Lal, S. 2025. Plasma biomarker data from the FIEBRE-Mozambique Cohort. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00004583.

Balanza, N, Bassat, Q, Kain, KC, Hopkins, H, Mabey, DC and Lal, S. Plasma biomarker data from the FIEBRE-Mozambique Cohort [Internet]. London School of Hygiene & Tropical Medicine; 2025. Available from: https://doi.org/10.17037/DATA.00004583.

Balanza, N, Bassat, Q, Kain, KC, Hopkins, H, Mabey, DC and Lal, S (2025). Plasma biomarker data from the FIEBRE-Mozambique Cohort. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00004583.

Description

An anonymised dataset of 1,955 paediatric and adult patients with febrile illness in southern Mozambique, who gave informed consent to participate in the prospective observational FIEBRE study between December 2018 and February 2021. Dataset contains variables on biomarker levels in plasma, demographic data, results of basic diagnostic tests and health status data, calculated clinical severity scores, and mortality and other adverse outcomes by day 28 follow-up.

Methods

Description of data capture

Study staff collected demographic data, took a standardised clinical history, and performed a physical examination. Lactate levels was measured on-site with a point-of-care analyser. Additional clinical data were collected for inpatients during admission and at discharge. In a follow-up visit at day 28, vital status and data related to the original illness episode were documented. All data were recorded electronically using Open Data Kit (ODK). Plasma samples were analysed at UHN (Toronto, Canada) for biomarkers of immune and endothelial activation using Luminex and ELISA, and the biomarker results were merged with the rest of the dataset using study IDs. Data cleaning involved consistency checks and verifying data integrity to ensure accuracy before statistical analysis and sharing. For biomarker data, duplicate measurements were averaged and concentrations outside the dynamic range were assigned the highest limit of the standard curve or a value of one-third of the lowest limit.

Data capture method

Physical measurements and tests

Data Collection Period

From	To
December 2018	March 2021

Date (Completed)

24 February 2025

Language(s) of written materials

English

People & Groups

Data Creators	Balanza, N, Bassat, Q, Kain, KC, Hopkins, H, Mabey, DC and Lal, S
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Dept of Clinical Research Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom

Projects

Funders

Project	Funder	Grant Number	Funder URI
Febrile Illness Evaluation in a Broad Range of Endemicities (FIEBRE) Study Consortium	Foreign, Commonwealth and Development Office	UNSPECIFIED	https://doi.org/10.13039/501100020171

Additional Information

Date Deposited	24 Feb 2025 15:38
Last Modified	25 Feb 2025 10:42
Publisher	London School of Hygiene & Tropical Medicine

Downloads

Data / Code

FIEBRE_biomarkers_data Request access

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Filename: FIEBRE_biomarkers_data.csv

Description: A dataset of 1,955 febrile patients in Mozambique from the FIEBRE study, including plasma biomarker levels, clinical data, and outcomes by day 28

Licence: Data Sharing Agreement

Content type: Dataset

File size: 53B

Mime-Type: text/plain

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