R code: why sensitive bacteria are resistant to hospital infection control

van Kleef, E, Luangasanatip, N, Bonten, MJ and Cooper, BS (2017). R code: why sensitive bacteria are resistant to hospital infection control. [Dataset]. Zenodo. https://doi.org/10.5281/zenodo.1045530
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This model simulates the transmission dynamics of two competing strains, i.e. a hospital-adapted resistant strain and a community-adapted sensitive strain, in the hospital and its catchment area. This release contains additional sensitivity analysis showing the impact of changing the degree of bacterial inference and mixing. It has been argued that since infection control measures, such as hand hygiene, should affect resistant and sensitive strains equally, observed discordant changes must have largely resulted from other factors, such as changes in antibiotic use. This model is used to test the validity of this reasoning.

Keywords

Mathematical Model, Antimicrobial resistance, Hospital Infection Control

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