Dataset for: "Comparing patterns of recent and remote Mycobacterium tuberculosis infection determined using the QuantiFERON-TB Gold Plus assay in a high TB burden setting"

Schaap, A and Amofa-Sekyi, M. 2024. Dataset for: "Comparing patterns of recent and remote Mycobacterium tuberculosis infection determined using the QuantiFERON-TB Gold Plus assay in a high TB burden setting". [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00003879.

Schaap, A and Amofa-Sekyi, M. Dataset for: "Comparing patterns of recent and remote Mycobacterium tuberculosis infection determined using the QuantiFERON-TB Gold Plus assay in a high TB burden setting" [Internet]. London School of Hygiene & Tropical Medicine; 2024. Available from: https://doi.org/10.17037/DATA.00003879.

Schaap, A and Amofa-Sekyi, M (2024). Dataset for: "Comparing patterns of recent and remote Mycobacterium tuberculosis infection determined using the QuantiFERON-TB Gold Plus assay in a high TB burden setting". [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00003879.

Description

Dataset to reproduce the statistical analysis of the patterns of interferon gamma responses in recent and remote infection as measured by the QuantiFERON-TB Gold Plus assay in the TREATS-TB incidence of infection Cohort. Each row represents a randomly selected adolescent or young adult of one of the 14 communities that were included in the cohort but restricted to those defined as recent or remote according to the criteria described in the paper. Apart from the QuantiFERON-TB Gold Plus tube responses, the data includes HIV-status, having a household contact on TB-treatment in the past or currently and demographic characteristics.

Methods

Description of data capture

All household members of randomly selected households were enumerated and eligible adolescents and young adults were invited to a health facility (Zambia) or clinical research site (South Africa) for enrolment. After informed consent. password-protected tablets were used by trained research assistants to record information on socio-demographic data, TB/HIV history, known TB risk factors, and other characteristics via the administration of a structured questionnaire. Rapid HIV-testing was done at the research site and results recorded using the same tablet. Blood samples were taken for QFT-Plus testing. Results of the QuantiFERON Gold Plus assay were afterwards combined with the questionnaire data using the unique (barcoded) identifier of the participant.

Data capture method

Questionnaire

Data Collection Period

From	To
July 2018	January 2021

Date (Date submitted to LSHTM repository)

10 May 2024

Language(s) of written materials

English

People & Groups

Data Creators	Schaap, A and Amofa-Sekyi, M
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre	ACT Consortium
Participating Institutions	Zambart, Lusaka, Zambia, Health Systems Trust, Cape Town, South Africa, London School of Hygiene & Tropical Medicine, London, United Kingdom, KNCV Tuberculosis Foundation, The Hague, Netherlands, HIV Clinical Trials Unit, Imperial College London, London, United Kingdom