Dataset for: "Comparing patterns of recent and remote Mycobacterium tuberculosis infection determined using the QuantiFERON-TB Gold Plus assay in a high TB burden setting" – User Guide

Persistent identifier

10.17037/DATA.00003879

Description

Dataset to reproduce the statistical analysis of the patterns of interferon gamma responses in recent and remote infection as measured by the QuantiFERON-TB Gold Plus assay in the TREATS-TB incidence of infection Cohort. Each row represents a randomly selected adolescent or young adult of one of the 14 communities that were included in the cohort but restricted to those defined as recent or remote according to the criteria described in the paper. Apart from the QuantiFERON-TB Gold Plus tube responses, the data includes HIV-status, having a household contact on TB-treatment in the past or currently and demographic characteristics.

Data collection methods

All household members of randomly selected households were enumerated and eligible adolescents and young adults were invited to a health facility (Zambia) or clinical research site (South Africa) for enrolment. After informed consent. password-protected tablets were used by trained research assistants to record information on socio-demographic data, TB/HIV history, known TB risk factors, and other characteristics via the administration of a structured questionnaire. Rapid HIV-testing was done at the research site and results recorded using the same tablet. Blood samples were taken for QFT-Plus testing. Results of the QuantiFERON Gold Plus assay were afterwards combined with the questionnaire data using the unique (barcoded) identifier of the participant.

Geographic regions

South Africa and Zambia

Key dates

Data collection period: July 2018 - January 2021
Date submitted to repository: 11 May 2024

Population

Population outlined in accompanying paper.

Participating institutions

Zambart, Lusaka, Zambia
Health Systems Trust, Cape Town, South Africa
London School of Hygiene & Tropical Medicine, London, United Kingdom
KNCV Tuberculosis Foundation, The Hague, Netherlands
HIV Clinical Trials Unit, Imperial College London, London, United Kingdom

Keywords

Tuberculosis infection, IGRA, recent infection, Remote infection, adolescent and young adults

Language of written material

English

Project information

Project name	Funder/sponsor	Grant number
TREATS	European and Developing Countries Clinical Trials Partnership	RIA2026S-1632

Creators

Forename	Surname	Faculty / Dept	Institution	Role
Albertus	Schaap	Dept of Clinical Research / Faculty of Infectious and Tropical Diseases	London School of Hygiene & Tropical Medicine	Data Creator
Modupe	Amofa-Sekyi	Dept of Clinical Research / Faculty of Infectious and Tropical Diseases	London School of Hygiene & Tropical Medicine	Data Creator

File description

Filename	Description	Access status	Licence
TREATS-ic-recentremote_data	Anonymised dataset collected for the TREATS TB-infection cohort for recent versus remote analysis	Open	Creative Commons Attribution (CCBY)
TREATS-ic-recentremote_data_HIV	Anonymised dataset containing HIV-status collected for the TREATS TB-infection cohort for recent versus remote analysis	Controlled	Data sharing agreement
TREATS-ic-recentremote_data_codebook	Codebook for the TREATS TB-infection cohort recent versus remote analysis dataset	Open	Creative Commons Attribution (CCBY)
3879-UserGuide	User guide for the TREATS TB-infection cohort recent versus remote analysis dataset	Open	Creative Commons Attribution (CCBY)