Aibana, O, Acharya, X, Huang, C, Becerra, MC, Galea, JT, Chiang, SS, Contreras, C, Calderon, R, Yataco, R, Velásquez, GE, Tintaya, K, Jimenez, J, Lecca, L and Murray, MB. 2016. Data for prospective cohort study. [Online]. PLOS ONE. Available from: https://doi.org/10.1371/journal.pone.0166333.s001
Aibana, O, Acharya, X, Huang, C, Becerra, MC, Galea, JT, Chiang, SS, Contreras, C, Calderon, R, Yataco, R, Velásquez, GE, Tintaya, K, Jimenez, J, Lecca, L and Murray, MB. Data for prospective cohort study [Internet]. PLOS ONE; 2016. Available from: https://doi.org/10.1371/journal.pone.0166333.s001
Aibana, O, Acharya, X, Huang, C, Becerra, MC, Galea, JT, Chiang, SS, Contreras, C, Calderon, R, Yataco, R, Velásquez, GE, Tintaya, K, Jimenez, J, Lecca, L and Murray, MB (2016). Data for prospective cohort study. [Data Collection]. PLOS ONE. https://doi.org/10.1371/journal.pone.0166333.s001
Description
Studies show obesity decreases risk of tuberculosis (TB) disease. There is limited evidence on whether high body mass index also protects against TB infection; how very high body mass indices influence TB risk; or whether nutritional status predicts this risk in children. We assessed the impact of body mass index on incident TB infection and disease among adults and children.
We conducted a prospective cohort study among household contacts of pulmonary TB cases in Lima, Peru. We determined body mass index at baseline and followed participants for one year for TB infection and disease. We used Cox proportional regression analyses to estimate hazard ratios for incident TB infection and disease. We enrolled 14,044 household contacts, and among 6853 negative for TB infection and disease at baseline, 1787 (26.1%) became infected. A total of 406 contacts developed secondary TB disease during follow-up. Body mass index did not predict risk of TB infection but overweight household contacts had significantly decreased risk of TB disease (HR 0.48; 95% CI 0.37–0.64; p <0.001) compared to those with normal weight. Among adults, body mass index ≥ 35 kg/m2 continued to predict a lower risk of TB disease (HR 0.30; 95% CI 0.12–0.74; p 0.009). We found no association between high body mass index and TB infection or disease among children under 12 years of age.
High body mass index protects adults against TB disease even at levels ≥ 35 kg/m2. This protective effect does not extend to TB infection and is not seen in children.
Data capture method | Field observation | ||||||||
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Date (Date published in a 3rd party system) | 12 November 2016 | ||||||||
Geographical area covered (offline during plugin upgrade) |
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Language(s) of written materials | English |
Data Creators | Aibana, O, Acharya, X, Huang, C, Becerra, MC, Galea, JT, Chiang, SS, Contreras, C, Calderon, R, Yataco, R, Velásquez, GE, Tintaya, K, Jimenez, J, Lecca, L and Murray, MB |
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LSHTM Faculty/Department | Faculty of Public Health and Policy > Dept of Public Health, Environments and Society |
Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
Date Deposited | 21 Nov 2016 12:30 |
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Last Modified | 15 Feb 2022 18:31 |
Publisher | PLOS ONE |