Validation of Correlates of Risk of TB Disease in High Risk Populations (CORTIS-HR) Study: Public, subject-level RISK11 signature scores and metadata

Mendelsohn, SC, Fiore-Gartland, A, Penn-Nicholson, A, Mulenga, H, Kimbung, S, Borate, B, Hadley, K, Hikuam, C, Musvosvi, M, Bilek, N, Erasmus, M, Jaxa, L, Raphela, R, Nombida, O, Kaskar, M, Sumner, TORCID logo, White, RGORCID logo, Innes, C, Brumskine, W, Hiemstra, A, Malherbe, ST, Hassan-Moosa, R, Tameris, M, Walzl, G, Naidoo, K, Churchyard, G, Scriba, TJ and Hatherill, M (2021). Validation of Correlates of Risk of TB Disease in High Risk Populations (CORTIS-HR) Study: Public, subject-level RISK11 signature scores and metadata. [Dataset]. University of Cape Town. https://doi.org/10.25375/uct.14176484.v1
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The Validation of Correlates of Risk of TB Disease in High Risk Populations (CORTIS-HR) Study, a companion study of the CORTIS-01 Trial (ClinicalTrials.gov: NCT02735590), was conducted to test the diagnostic and prognostic performance of the RISK11 biomarker for tuberculosis (TB) disease in people living with HIV (PLHIV) in an ambulant community setting. The “CORTIS-HR pubdata.csv” is a public, subject-level dataset for the CORTIS-HR study containing key variables necessary to reconstruct the study findings. A data dictionary is provided below. The “CORTIS-HR PCR data.csv” provides subject-level TaqMan qPCR probe raw CT (cycle threshold) gene expression data from the Fluidigm microfluidic 96.96 Gene Expression Integrated Fluidic Circuits (chips) with sample quality control (“SAMPLE_QC”) results. Analyses of the qPCR probe data are ongoing; the embargo on this data ends 1 July 2021 when the data will be available on ZivaHub. “CORTIS-HR Protocol Version 1.0.pdf” and “CORTIS-HR SAP Version 1.0.pdf” are the protocol and the statistical analysis plan for the study respectively and have been included for reference.

Keywords

Tuberculosis; HIV; Diagnostic; Prognostic; IGRA; RISK11; Transcriptomic; RNA; Biomarker; Signature; Incipient TB; Sub-clinical TB; TB; Host-response; CORTIS-HR; CORTIS

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