Mendelsohn, SC, Fiore-Gartland, A, Penn-Nicholson, A, Mulenga, H, Kimbung, S, Borate, B, Hadley, K, Hikuam, C, Musvosvi, M, Bilek, N, Erasmus, M, Jaxa, L, Raphela, R, Nombida, O, Kaskar, M, Sumner, T, White, RG, Innes, C, Brumskine, W, Hiemstra, A, Malherbe, ST, Hassan-Moosa, R, Tameris, M, Walzl, G, Naidoo, K, Churchyard, G, Scriba, TJ and Hatherill, M. 2021. Validation of Correlates of Risk of TB Disease in High Risk Populations (CORTIS-HR) Study: Public, subject-level RISK11 signature scores and metadata. [Online]. University of Cape Town. Available from: https://doi.org/10.25375/uct.14176484.v1
Mendelsohn, SC, Fiore-Gartland, A, Penn-Nicholson, A, Mulenga, H, Kimbung, S, Borate, B, Hadley, K, Hikuam, C, Musvosvi, M, Bilek, N, Erasmus, M, Jaxa, L, Raphela, R, Nombida, O, Kaskar, M, Sumner, T, White, RG, Innes, C, Brumskine, W, Hiemstra, A, Malherbe, ST, Hassan-Moosa, R, Tameris, M, Walzl, G, Naidoo, K, Churchyard, G, Scriba, TJ and Hatherill, M. Validation of Correlates of Risk of TB Disease in High Risk Populations (CORTIS-HR) Study: Public, subject-level RISK11 signature scores and metadata [Internet]. University of Cape Town; 2021. Available from: https://doi.org/10.25375/uct.14176484.v1
Mendelsohn, SC, Fiore-Gartland, A, Penn-Nicholson, A, Mulenga, H, Kimbung, S, Borate, B, Hadley, K, Hikuam, C, Musvosvi, M, Bilek, N, Erasmus, M, Jaxa, L, Raphela, R, Nombida, O, Kaskar, M, Sumner, T, White, RG, Innes, C, Brumskine, W, Hiemstra, A, Malherbe, ST, Hassan-Moosa, R, Tameris, M, Walzl, G, Naidoo, K, Churchyard, G, Scriba, TJ and Hatherill, M (2021). Validation of Correlates of Risk of TB Disease in High Risk Populations (CORTIS-HR) Study: Public, subject-level RISK11 signature scores and metadata. [Data Collection]. University of Cape Town. https://doi.org/10.25375/uct.14176484.v1
Description
The Validation of Correlates of Risk of TB Disease in High Risk Populations (CORTIS-HR) Study, a companion study of the CORTIS-01 Trial (ClinicalTrials.gov: NCT02735590), was conducted to test the diagnostic and prognostic performance of the RISK11 biomarker for tuberculosis (TB) disease in people living with HIV (PLHIV) in an ambulant community setting. The “CORTIS-HR pubdata.csv” is a public, subject-level dataset for the CORTIS-HR study containing key variables necessary to reconstruct the study findings. A data dictionary is provided below. The “CORTIS-HR PCR data.csv” provides subject-level TaqMan qPCR probe raw CT (cycle threshold) gene expression data from the Fluidigm microfluidic 96.96 Gene Expression Integrated Fluidic Circuits (chips) with sample quality control (“SAMPLE_QC”) results. Analyses of the qPCR probe data are ongoing; the embargo on this data ends 1 July 2021 when the data will be available on ZivaHub. “CORTIS-HR Protocol Version 1.0.pdf” and “CORTIS-HR SAP Version 1.0.pdf” are the protocol and the statistical analysis plan for the study respectively and have been included for reference.
Keywords
| Data capture method | Other |
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| Date (Date published in a 3rd party system) | 29 March 2021 |
| Language(s) of written materials | English |
| Data Creators | Mendelsohn, SC, Fiore-Gartland, A, Penn-Nicholson, A, Mulenga, H, Kimbung, S, Borate, B, Hadley, K, Hikuam, C, Musvosvi, M, Bilek, N, Erasmus, M, Jaxa, L, Raphela, R, Nombida, O, Kaskar, M, Sumner, T, White, RG, Innes, C, Brumskine, W, Hiemstra, A, Malherbe, ST, Hassan-Moosa, R, Tameris, M, Walzl, G, Naidoo, K, Churchyard, G, Scriba, TJ and Hatherill, M |
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| LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology |
| Research Centre | TB Centre |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Funders |
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| Date Deposited | 22 Apr 2021 13:38 |
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| Last Modified | 22 Sep 2021 15:50 |
| Publisher | University of Cape Town |
