A seroepidemiological study of serogroup A meningococcal infection in the African meningitis belt

Manigart, O; Trotter, C; Findlow, H; Assefa, A; Mihret, W; Demisse, TM; Yeshitela, B; Osei, I; Hodgson, A; Quaye, SL; Sow, S; Coulibaly, M; Diallo, K; Traore, A; Collard, J; Boukary, R; Djermakoye, O; Mahamane, AE; Jusot, J; Sokhna, C; Alavo, S; Doucoure, S; Ba, EH; Dieng, M; Diallo, A; Daugla, DM; Omotara, B; Chandramohan, D

; Hassan-King, M; Nascimento, M; Woukeu, A; Borrow, R; Stuart, J and Greenwood, B

(2016). A seroepidemiological study of serogroup A meningococcal infection in the African meningitis belt. [Dataset]. London School of Hygiene & Tropical Medicine, London, United Kingdom. 10.17037/DATA.34.

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The dataset contains results of a cross-sectional survey of meningococcal carriage and immunity performed in several countries of the African meningitis belt in 2010. A standardised enzyme-linked immunosorbent assay (ELISA) for measuring meningococcal serogroup A IgG antibodies was used to measure antibody concentrations in 3930 individuals. Anonymised information on the age, sex, residence, carriage status and other risk factors is included.

Alternative Title

Une étude séro-épidémiologique de l' infection à méningocoque du sérogroupe A dans la ceinture africaine de la méningite

Additional Information

HTML copy of codebook and user guide added to record on 28 Jan 2025 (previously PDF). Consult codebook for variable list and access conditions.

Keywords

Meningitis; Neisseria meningitidis; ELISA; Antibody; Seroprevalence

Item Type	Dataset
Resource Type	Resource Type Resource Description Dataset Quantitative
Description of data capture	Cross-sectional meningococcal carriage surveys were conducted in seven countries across the meningitis belt between July 1st 2010 and December 31st 2010. Subjects were selected randomly from within populations which were part of a routine demographic survey system (DHSS) or in which a census had recently been performed. The study population was recruited from urban and rural populations and stratified into four age groups: < 5 years, 5-14 years, 15-29 years and 30 years or older. A short questionnaire collecting demographic details and information on potential risk factors was completed for each participant and each household recruited. Blood samples were collected from the first 100 subjects surveyed within each of the four age bands in both urban and rural study sites, giving an overall target of 800 samples per country. This target was achieved, except in Senegal where there was some resistance to the collection of blood samples. A 5 mL sample was collected, serum separated within six hours of collection and then stored at -20°C until assayed.
Capture method	Questionnaire
Collection Period	From To 1 July 2010 31 December 2010
Date	21 January 2016
Geographical area covered (offline during plugin upgrade)	North East South West 13.7661 45.1318 4.49155 34.8486 21.384 15.4248 13.0822 5.22949 18.4926 3.12012 13.8514 -16.3916 13.1677 14.0186 5.62965 3.73535
Language(s) of written materials	English
Creator(s)	Manigart, O; Trotter, C; Findlow, H; Assefa, A; Mihret, W; Demisse, TM; Yeshitela, B; Osei, I; Hodgson, A; Quaye, SL; Sow, S; Coulibaly, M; Diallo, K; Traore, A; Collard, J; Boukary, R; Djermakoye, O; Mahamane, AE; Jusot, J; Sokhna, C; Alavo, S; Doucoure, S; Ba, EH; Dieng, M; Diallo, A; Daugla, DM; Omotara, B; Chandramohan, D ; Hassan-King, M; Nascimento, M; Woukeu, A; Borrow, R; Stuart, J and Greenwood, B
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom; University of Cambridge, Cambridge, United Kingdom; Public Health England; Armauer Hansen Research Institute; Navrongo Health Research Centre, Navrongo, Ghana; Centre pour les Vaccins en Développement; Centre de Recherche Médicale et Sanitaire; Institut de Recherche pour le Développement; Centre de Support en Santé International; University of Maiduguri, Maiduguri, Nigeria
Funders	Project Funder Grant Number Funder URI The African Meningococcal Carriage Consortium (MenAfriCar) Wellcome Trust 086546 http://dx.doi.org/10.13039/100010269 The African Meningococcal Carriage Consortium (MenAfriCar) Bill and Melinda Gates Foundation OPP51251 http://dx.doi.org/10.13039/100000865
Date Deposited	27 Jan 2016 12:52
Last Modified	28 Jan 2025 10:38
Publisher	London School of Hygiene & Tropical Medicine

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Dept of Disease Control

Data / Code

MenAfriCar_ELISA.csv

subject: Data
lock: Restricted to Request access for all
copyright: Available under Data Sharing Agreement
info: Anonymised dataset containing variables on meningococcal carriage status, strain details, commensal Neisseria carriage status, recent vaccination history, serogroup A specific IgG ELISA antibody concentration, and other details.
description: text/plain
folder_info: 64B

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Documentation

MenAfriCar_ELISA_codebook.html

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info: MenAfriCar ELISA codebook
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ConsentFormAdults.pdf

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0034_UserGuide.html

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Study Instrument

Adult_Questionnaire.pdf

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info: Adult Short Individual Questionnaire (ASIQ)
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Children_Questionnaire.pdf

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info: Children Short Individual Questionnaire (CSIQ)
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Household_Questionnaire.pdf

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info: Short Household Questionnaire (SHQ)
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