S1 Data for: "A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia"
James, P
, Jawla, O, Mohammed, N
, Ceesay, K, Akemokwe, F, Sonko, B, Sise, E, Prentice, A
and Silver, M
(2019).
S1 Data for: "A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia".
[Dataset].
PLOS Medicine.
https://doi.org/10.1371/journal.pmed.1002870.s007
Infant DNA methylation profiles are associated with their mother’s periconceptional nutritional status. DNA methylation relies on nutritional inputs for one-carbon metabolic pathways, including the efficient recycling of homocysteine. This randomised controlled trial in nonpregnant women in rural Gambia tests the efficacy of a novel nutritional supplement designed to improve one-carbon-related nutrient status by reducing plasma homocysteine, and assesses its potential future use in preconception trials.
Keywords
plasma homocysteine, DNA methylation profiles, Pregnancy, Metabolic pathways, Blood plasma, DNA methylation, Folic acid, Blood pressure, B vitamins, United NationsItem Type | Dataset |
---|---|
Capture method | Experiment |
Date | 13 August 2019 |
Language(s) of written materials | English |
Creator(s) |
James, P |
LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) MRC Unit The Gambia at LSHTM > GM-Disease Control and Elimination Theme MRC Unit The Gambia at LSHTM > GM-Nutrition Theme |
Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
Date Deposited | 22 Aug 2019 15:27 |
Last Modified | 26 Jun 2025 09:38 |
Publisher | PLOS Medicine |
No files available. Please consult associated links.
- Data record – Figshare (Data)
- Data download – Figshare (Online Data Resource)
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ORCID: https://orcid.org/0000-0001-5448-8193
ORCID: https://orcid.org/0000-0002-4067-1103
ORCID: https://orcid.org/0000-0001-5389-451X
ORCID: https://orcid.org/0000-0002-3852-9677