James, P, Jawla, O, Mohammed, N, Ceesay, K, Akemokwe, F, Sonko, B, Sise, E, Prentice, A and Silver, M. 2019. A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia. [Online]. PLOS Medicine. Available from:
James, P, Jawla, O, Mohammed, N, Ceesay, K, Akemokwe, F, Sonko, B, Sise, E, Prentice, A and Silver, M. A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia [Internet]. PLOS Medicine; 2019. Available from:
James, P, Jawla, O, Mohammed, N, Ceesay, K, Akemokwe, F, Sonko, B, Sise, E, Prentice, A and Silver, M (2019). A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia. [Data Collection]. PLOS Medicine.
Description
Infant DNA methylation profiles are associated with their mother’s periconceptional nutritional status. DNA methylation relies on nutritional inputs for one-carbon metabolic pathways, including the efficient recycling of homocysteine. This randomised controlled trial in nonpregnant women in rural Gambia tests the efficacy of a novel nutritional supplement designed to improve one-carbon-related nutrient status by reducing plasma homocysteine, and assesses its potential future use in preconception trials.
| Data capture method | Experiment |
|---|---|
| Date (Date published in a 3rd party system) | 13 August 2019 |
| Language(s) of written materials | English |
| Data Creators | James, P, Jawla, O, Mohammed, N, Ceesay, K, Akemokwe, F, Sonko, B, Sise, E, Prentice, A and Silver, M |
|---|---|
| LSHTM Faculty/Department | MRC Unit The Gambia at LSHTM |
| Participating Institutions | London School of Hygiene & Tropical Medicine |
| Date Deposited | 22 Aug 2019 15:27 |
|---|---|
| Last Modified | 08 Jul 2021 12:52 |
| Publisher | PLOS Medicine |
