Ashton, P, Thanh, L, Trieu, P, Van Anh, D, Trinh, N, Beardsley, J, Kibengo, F, Chierakul, W, Dance, D, Rattanavong, S, Davong, V, Hung, L, Chau, N, Tung, N, Chan, A, Thwaites, G, Lalloo, D, Anscombe, C, Nhat, L, Perfect, J, Dougan, G, Baker, S, Harris, S and Day, J. 2019. Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans. [Online]. Nature Communications. Available from: https://doi.org/10.1038/s41467-019-10092-5
Ashton, P, Thanh, L, Trieu, P, Van Anh, D, Trinh, N, Beardsley, J, Kibengo, F, Chierakul, W, Dance, D, Rattanavong, S, Davong, V, Hung, L, Chau, N, Tung, N, Chan, A, Thwaites, G, Lalloo, D, Anscombe, C, Nhat, L, Perfect, J, Dougan, G, Baker, S, Harris, S and Day, J. Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans [Internet]. Nature Communications; 2019. Available from: https://doi.org/10.1038/s41467-019-10092-5
Ashton, P, Thanh, L, Trieu, P, Van Anh, D, Trinh, N, Beardsley, J, Kibengo, F, Chierakul, W, Dance, D, Rattanavong, S, Davong, V, Hung, L, Chau, N, Tung, N, Chan, A, Thwaites, G, Lalloo, D, Anscombe, C, Nhat, L, Perfect, J, Dougan, G, Baker, S, Harris, S and Day, J (2019). Three phylogenetic groups have driven the recent population expansion of Cryptococcus neoformans. [Data Collection]. Nature Communications. https://doi.org/10.1038/s41467-019-10092-5
Description
Cryptococcus neoformans (C. neoformans var. grubii) is an environmentally acquired pathogen causing 181,000 HIV-associated deaths each year. We sequenced 699 isolates, primarily C. neoformans from HIV-infected patients, from 5 countries in Asia and Africa. The phylogeny of C. neoformans reveals a recent exponential population expansion, consistent with the increase in the number of susceptible hosts. In our study population, this expansion has been driven by three sub-clades of the C. neoformans VNIa lineage; VNIa-4, VNIa-5 and VNIa-93. These three sub-clades account for 91% of clinical isolates sequenced in our study. Combining the genome data with clinical information, we find that the VNIa-93 sub-clade, the most common sub-clade in Uganda and Malawi, was associated with better outcomes than VNIa-4 and VNIa-5, which predominate in Southeast Asia. This study lays the foundation for further work investigating the dominance of VNIa-4, VNIa-5 and VNIa-93 and the association between lineage and clinical phenotype.
Keywords
| Data capture method | Experiment |
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| Date (Date published in a 3rd party system) | 2 May 2019 |
| Language(s) of written materials | English |
| Data Creators | Ashton, P, Thanh, L, Trieu, P, Van Anh, D, Trinh, N, Beardsley, J, Kibengo, F, Chierakul, W, Dance, D, Rattanavong, S, Davong, V, Hung, L, Chau, N, Tung, N, Chan, A, Thwaites, G, Lalloo, D, Anscombe, C, Nhat, L, Perfect, J, Dougan, G, Baker, S, Harris, S and Day, J |
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| LSHTM Faculty/Department | MRC/UVRI and LSHTM Uganda Research Unit |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Funders |
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| Date Deposited | 19 Jul 2019 13:39 |
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| Last Modified | 20 Aug 2021 15:00 |
| Publisher | Nature Communications |
