In-depth proteomic characterization of Schistosoma haematobium: Towards the development of new tools for elimination

Sotillo, J, Pearson, MS, Becker, L, Mekonnen, GG, Amoah, AS

, Dam, Gv, Corstjens, PL, Murray, J, Mduluza, T, Mutapi, F and Loukas, A (2019). In-depth proteomic characterization of Schistosoma haematobium: Towards the development of new tools for elimination. [Dataset]. PLoS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0007362.s001

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Schistosomiasis is a neglected disease affecting hundreds of millions worldwide. Of the three main species affecting humans, Schistosoma haematobium is the most common, and is the leading cause of urogenital schistosomiasis. S. haematobium infection can cause different urogenital clinical complications, particularly in the bladder, and furthermore, this parasite has been strongly linked with squamous cell carcinoma. A comprehensive analysis of the molecular composition of its different proteomes will contribute to developing new tools against this devastating disease.

Keywords

In-depth proteomic characterization, tegument extracts, egg proteomes, OFFGEL, protein fractionation approach, infection, elimination Background Schistosomiasis, Schistosoma haematobium, high-throughput mass spectrometry

Item Type	Dataset
Capture method	Experiment
Date	15 May 2019
Language(s) of written materials	English
Creator(s)	Sotillo, J, Pearson, MS, Becker, L, Mekonnen, GG, Amoah, AS , Dam, Gv, Corstjens, PL, Murray, J, Mduluza, T, Mutapi, F and Loukas, A
LSHTM Faculty/Department	Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom
Funders	Project Funder Grant Number Funder URI UNSPECIFIED National Health and Medical Research Council 1037304 http://dx.doi.org/10.13039/501100000925
Date Deposited	18 Jul 2019 14:57
Last Modified	26 Jun 2025 10:14
Publisher	PLoS Neglected Tropical Diseases