PBMC expression profiles of BCG vaccine protected infants and of BCG vaccinated infants who develop tuberculosis disease

Fletcher, HA

; Filali-Mouhim, A; Nemes, E; Hawkridge, A; Keyser, A; Njikan, S; Hatherill, M; Scriba, TJ; Abel, B; Kagina, BM; Veldsman, A; Agudelo, NM; Kaplan, G; Hussey, GD; Sekaly, R and Hanekom, WA (2014). PBMC expression profiles of BCG vaccine protected infants and of BCG vaccinated infants who develop tuberculosis disease. [Dataset]. NCBI Gene Expression Omnibus. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE20716

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Analysis of PBMC from 10 week old infants vaccinated with BCG at birth. During follow-up 26 infants developed tuberculosis (TB) (non-protected by BCG) and 20 infants did not develop TB despite documented exposure (protected by BCG). PBMC were stimulated with media only or reconstituted BCG for 4 and 12 hours. Results provide insight into the mechanisms behind the failure of BCG to protect against disease.

Keywords

Tuberculosis; Vaccine; Correlates of risk; Systems biology

Item Type	Dataset
Resource Type	Resource Type Resource Description Dataset Quantitative
Capture method	Experiment
Date	30 June 2014
Language(s) of written materials	English
Creator(s)	Fletcher, HA ; Filali-Mouhim, A; Nemes, E; Hawkridge, A; Keyser, A; Njikan, S; Hatherill, M; Scriba, TJ; Abel, B; Kagina, BM; Veldsman, A; Agudelo, NM; Kaplan, G; Hussey, GD; Sekaly, R and Hanekom, WA
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection (-2019)
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom
Date Deposited	11 Jan 2019 10:06
Last Modified	08 Jul 2021 12:49
Publisher	NCBI Gene Expression Omnibus