PBMC expression profiles of BCG vaccine protected infants and of BCG vaccinated infants who develop tuberculosis disease

Fletcher, HA

, Filali-Mouhim, A, Nemes, E, Hawkridge, A, Keyser, A, Njikan, S, Hatherill, M, Scriba, TJ, Abel, B, Kagina, BM, Veldsman, A, Agudelo, NM, Kaplan, G, Hussey, GD, Sekaly, R and Hanekom, WA (2014). PBMC expression profiles of BCG vaccine protected infants and of BCG vaccinated infants who develop tuberculosis disease. [Dataset]. NCBI Gene Expression Omnibus. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE20716

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Analysis of PBMC from 10 week old infants vaccinated with BCG at birth. During follow-up 26 infants developed tuberculosis (TB) (non-protected by BCG) and 20 infants did not develop TB despite documented exposure (protected by BCG). PBMC were stimulated with media only or reconstituted BCG for 4 and 12 hours. Results provide insight into the mechanisms behind the failure of BCG to protect against disease.

Keywords

Tuberculosis, Vaccine, Correlates of risk, Systems biology

Item Type	Dataset
Capture method	Experiment
Date	30 June 2014
Language(s) of written materials	English
Creator(s)	Fletcher, HA , Filali-Mouhim, A, Nemes, E, Hawkridge, A, Keyser, A, Njikan, S, Hatherill, M, Scriba, TJ, Abel, B, Kagina, BM, Veldsman, A, Agudelo, NM, Kaplan, G, Hussey, GD, Sekaly, R and Hanekom, WA
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection (-2019)
Participating Institutions	London School of Hygiene & Tropical Medicine, London, United Kingdom
Date Deposited	11 Jan 2019 10:06
Last Modified	08 Jul 2021 12:49
Publisher	NCBI Gene Expression Omnibus