Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda

Lule, SA, Mawa, P, Nkurunungi, G, Nampijja, M, Kizito, D, Akello, F, Muhangi, L, Elliott, A and Webb, EL. 2014. Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda. [Online]. Vaccine. Available from: https://doi.org/10.1016/j.vaccine.2014.12.015.

Lule, SA, Mawa, P, Nkurunungi, G, Nampijja, M, Kizito, D, Akello, F, Muhangi, L, Elliott, A and Webb, EL. Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda. [Internet] LSHTM Data Compass. Vaccine; 2014. Available from: https://doi.org/10.1016/j.vaccine.2014.12.015.

Lule, SA, Mawa, P, Nkurunungi, G, Nampijja, M, Kizito, D, Akello, F, Muhangi, L, Elliott, A and Webb, EL (2014). Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda. [Data Collection]. Vaccine. https://doi.org/10.1016/j.vaccine.2014.12.015.

Description

Description of data capture Blood samples from age one and five years were stimulated using crude culture filtrates of Mycobacterium tuberculosis in a six-day whole blood assay. IFN-γ, IL-5, IL-13 and IL-10 production was measured. LTBI at five years was determined using T-SPOT.TB® assay. Associations with LTBI at five years were assessed using multivariable logistic regression. Multiple linear regression with bootstrapping was used to determine factors associated with cytokine responses at age five years. The study found that LTBI prevalence was 9% at age five years. Only urban residence and history of TB contact/disease were positively associated with LTBI. BCG vaccine strain, LTBI, HIV infection, asymptomatic malaria, growth z-scores, childhood anthelminthic treatment and maternal BCG scar were associated with cytokine responses at age five. Cytokine responses at one year were not associated with acquisition of LTBI by five years of age.
Data capture method Experiment: Field Intervention
Date (Published in a 3rd party system) 19 December 2014
Geographical area covered
North LatitudeEast LongitudeSouth LatitudeWest Longitude
0.096836432.51150.021949232.4143
Language(s) of written materials English
Data Creators Lule, SA, Mawa, P, Nkurunungi, G, Nampijja, M, Kizito, D, Akello, F, Muhangi, L, Elliott, A and Webb, EL
LSHTM Faculty/Department Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Participating Institutions MRC/UVRI Uganda Research Unit on AIDS, Entebbe Hospital, Uganda, London School of Hygiene & Tropical Medicine
Funders
ProjectFunderGrant NumberFunder URI
Entebbe Mother and Baby StudyUNSPECIFIED063693; 079110UNSPECIFIED
UNSPECIFIEDUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Depositor Gareth Knight
Date Deposited 03 Nov 2015 11:19
Last Modified 05 Aug 2016 14:46
Publisher Vaccine

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Description: Factors associated with T-SPOT. TB among five year old children vaccinated with BCG in infancy

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Filename: Table2.csv

Description: Crude associations with cytokine response to crude culture filtrate proteins of Mycobacterium tuberculosis in five year olds who received BCG immunisation at birth

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Filename: Table3.csv

Description: Factors associated with the cytokine response to crude culture filtrate proteins of Mycobacterium tuberculosis in five year olds who received BCG immunisation at birth, after adjustment for potential confounders.

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Filename: Table4.csv

Description: Associations between cytokine responses to mycobacterial antigens at age one and odds of subsequent infection with M. tuberculosis infection by five years of age, among 58 children with a history of tuberculosis exposure

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Description: Distribution of cytokine responses to Mycobacterium tuberculosis crude culture filtrate protein at age one and five years, by BCG vaccine strain received in infancy

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Documentation

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Description: Hierarchical causal diagram model applied in study

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