Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda
Lule, SA, Mawa, P, Nkurunungi, G
, Nampijja, M, Kizito, D, Akello, F, Muhangi, L, Elliott, A and Webb, EL
(2014).
Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda.
[Dataset].
Vaccine.
10.1016/j.vaccine.2014.12.015.
, Nampijja, M, Kizito, D, Akello, F, Muhangi, L, Elliott, A and Webb, EL
(2014).
Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda.
[Dataset].
Vaccine.
10.1016/j.vaccine.2014.12.015.
BCG is used widely as the sole licensed vaccine against tuberculosis, but it has variable efficacy and the reasons for this are still unclear. No reliable biomarkers to predict future protection against, or acquisition of, TB infection following immunisation have been identified. Lessons from BCG could be valuable in the development of effective tuberculosis vaccines. The Entebbe Mother and Baby Study birth cohort in Uganda investigated factors associated with latent tuberculosis infection (LTBI) and with cytokine response to mycobacterial antigen at age five years. It also investigated whether cytokine responses at one year were associated with LTBI at five years of age. This dataset contains tabular data associated with the analysis
Keywords
Tuberculosis, HIV, Helminth, Pregnancy, Bacille Calmette–Guerin, Crude culture filtrate protein| Item Type | Dataset |
|---|---|
| Description of data capture | Blood samples from age one and five years were stimulated using crude culture filtrates of Mycobacterium tuberculosis in a six-day whole blood assay. IFN-γ, IL-5, IL-13 and IL-10 production was measured. LTBI at five years was determined using T-SPOT.TB® assay. Associations with LTBI at five years were assessed using multivariable logistic regression. Multiple linear regression with bootstrapping was used to determine factors associated with cytokine responses at age five years. The study found that LTBI prevalence was 9% at age five years. Only urban residence and history of TB contact/disease were positively associated with LTBI. BCG vaccine strain, LTBI, HIV infection, asymptomatic malaria, growth z-scores, childhood anthelminthic treatment and maternal BCG scar were associated with cytokine responses at age five. Cytokine responses at one year were not associated with acquisition of LTBI by five years of age. |
| Capture method | Experiment: Field Intervention |
| Date | 19 December 2014 |
| Geographical area covered (offline during plugin upgrade) |
North Latitude East Longitude South Latitude West Longitude 0.0968364 32.5115 0.0219492 32.4143 |
| Language(s) of written materials | English |
| Creator(s) |
Lule, SA, Mawa, P, Nkurunungi, G, Nampijja, M, Kizito, D, Akello, F, Muhangi, L, Elliott, A and Webb, EL
|
| LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection (-2019) |
| Participating Institutions | MRC/UVRI Uganda Research Unit on AIDS, Entebbe Hospital, Uganda, London School of Hygiene & Tropical Medicine |
| Funders |
Project Funder Grant Number Funder URI |
| Date Deposited | 03 Nov 2015 11:19 |
| Last Modified | 27 Apr 2022 17:38 |
| Publisher | Vaccine |
Figure1.jpg
-
subject - Documentation
- Creative Commons: Attribution
- Available under Creative Commons: Attribution 3.0
-
info - Hierarchical causal diagram model applied in study
image - image/jpeg
- folder_info
- 44kB
Figure2.jpg
-
subject - Graphical representation of data
- Creative Commons: Attribution
- Available under Creative Commons: Attribution 3.0
-
info - Distribution of cytokine responses to Mycobacterium tuberculosis crude culture filtrate protein at age one and five years, by BCG vaccine strain received in infancy
image - image/jpeg
- folder_info
- 54kB
Table1.csv
-
subject - Data
- Creative Commons: Attribution
- Available under Creative Commons: Attribution 3.0
-
info - Factors associated with T-SPOT. TB among five year old children vaccinated with BCG in infancy
description - text/plain
- folder_info
- 3kB
Table2.csv
-
subject - Data
- Creative Commons: Attribution
- Available under Creative Commons: Attribution 3.0
-
info - Crude associations with cytokine response to crude culture filtrate proteins of Mycobacterium tuberculosis in five year olds who received BCG immunisation at birth
description - text/plain
- folder_info
- 5kB
Table3.csv
-
subject - Data
- Creative Commons: Attribution
- Available under Creative Commons: Attribution 3.0
-
info - Factors associated with the cytokine response to crude culture filtrate proteins of Mycobacterium tuberculosis in five year olds who received BCG immunisation at birth, after adjustment for potential confounders.
description - text/plain
- folder_info
- 1kB
Table4.csv
-
subject - Data
- Creative Commons: Attribution
- Available under Creative Commons: Attribution 3.0
-
info - Associations between cytokine responses to mycobacterial antigens at age one and odds of subsequent infection with M. tuberculosis infection by five years of age, among 58 children with a history of tuberculosis exposure
description - text/plain
- folder_info
- 546B
Downloads
