Claessens, A, Hamilton, WL, Kekre, M, Otto, TD, Faizullabhoy, A, Rayner, JC and Kwiatkowski, D. 2014. Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis. [Online]. PLOS Genetics. Available from: https://doi.org/10.1371/journal.pgen.1004812.
Claessens, A, Hamilton, WL, Kekre, M, Otto, TD, Faizullabhoy, A, Rayner, JC and Kwiatkowski, D. Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis. [Internet] LSHTM Data Compass. PLOS Genetics; 2014. Available from: https://doi.org/10.1371/journal.pgen.1004812.
Claessens, A, Hamilton, WL, Kekre, M, Otto, TD, Faizullabhoy, A, Rayner, JC and Kwiatkowski, D (2014). Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis. [Data Collection]. PLOS Genetics. https://doi.org/10.1371/journal.pgen.1004812.
Description
Supplementary data for PLOS Genetics paper on the creation of antigenic diversity in Plasmodium falciparum through structured rearrangement of Var genes during mitosis.
Data capture method | Experiment: Laboratory |
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Date (Published in a 3rd party system) | 18 December 2014 |
Language(s) of written materials | English |
Data Creators | Claessens, A, Hamilton, WL, Kekre, M, Otto, TD, Faizullabhoy, A, Rayner, JC and Kwiatkowski, D |
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LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology |
Research Centre | Malaria Centre |
Participating Institutions | Wellcome Trust Sanger Institute, University of Oxford, London School of Hygiene & Tropical Medicine |
Depositor | Gareth Knight |
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Date Deposited | 20 Oct 2015 09:51 |
Last Modified | 05 Aug 2016 14:12 |
Publisher | PLOS Genetics |
Downloads
Data
Filename: S1_Table.xlsx
Description: Genome coverage for each subclone
Content type: Dataset
File size: 70kB
Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Filename: S2_Table.xlsx
Description: SNPs identified in clone trees
Content type: Dataset
File size: 69kB
Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Filename: S3_Table.xlsx
Description: Structural variants identified in the 3D7 clone tree, represented in Fig. 1
Content type: Dataset
File size: 141kB
Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Filename: S4_Table.xlsx
Description: All var gene recombinations
Content type: Dataset
File size: 96kB
Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Filename: S5_Table.xlsx
Description: Mitotic point mutation rates and var gene recombination rates measured from clone trees
Content type: Dataset
File size: 55kB
Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Filename: S6_Table.xlsx
Description: Primers used for validating point mutations and var gene recombination by PCR amplification and capillary sequencing
Content type: Dataset
File size: 11kB
Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Filename: S7_Table.xlsx
Description: Crosses progeny culture time and var gene recombinations
Content type: Dataset
File size: 38kB
Mime-Type: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
Data Visualisation
Filename: S1_Fig.pdf
Description: Generating clone trees
Content type: Textual content
File size: 782kB
Mime-Type: application/pdf
Filename: S2_Fig.pdf
Description: Chimeric var gene created by recombination
Content type: Still Image
File size: 336kB
Mime-Type: application/pdf
Filename: S3_Fig.pdf
Description: Example of 7 recombination events within var gene exon2 in 3D7_1b
Content type: Still Image
File size: 967kB
Mime-Type: application/pdf
Filename: S4_Fig.pdf
Description: Triple recombination event within less than 50 bp
Content type: Still Image
File size: 323kB
Mime-Type: application/pdf
Filename: S5_Fig.pdf
Description: Duplications in internal var gene clusters can also generate chimeras
Content type: Still Image
File size: 703kB
Mime-Type: application/pdf
Filename: S6_Fig.pdf
Description: Another example of internal var gene clusters generating chimeras
Content type: Still Image
File size: 602kB
Mime-Type: application/pdf
Filename: S7_Fig.pdf
Description: Evolution of a var gene
Content type: Still Image
File size: 583kB
Mime-Type: application/pdf
Filename: S10_Fig.pdf
Description: Defining identity blocks. Var B/C genes recombine (A) ClustalW alignment of Dd2var34 and Dd2var45 at a crossover
Content type: Still Image
File size: 186kB
Mime-Type: application/pdf
Filename: S13_Fig.eps
Description: Distribution of var exon 1 recombination within each domain class
Content type: Still Image
File size: 469kB
Mime-Type: application/postscript
Filename: S14_Fig.eps
Description: No recombination hotspot within DBL domains
Content type: Still Image
File size: 181kB
Mime-Type: application/postscript
Filename: S15_Fig.pdf
Description: No conserved motifs within Identity Blocks.
Content type: Still Image
File size: 173kB
Mime-Type: application/pdf
Filename: S8_Fig.png
Description: All var exon 1 translocations identified in this study
Content type: Still Image
File size: 4MB
Mime-Type: image/png
Filename: S9_Fig.png
Description: Group B/C var genes do not necessarily recombine with var genes of highest similarity
Content type: Still Image
File size: 2MB
Mime-Type: image/png
Filename: S11_Fig.png
Description: Recombination in var genes occurs where sequences are similar
Content type: Still Image
File size: 1MB
Mime-Type: image/png