LSHTM Data Compass

Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis

Claessens, A, Hamilton, WL, Kekre, M, Otto, TD, Faizullabhoy, A, Rayner, JC and Kwiatkowski, D (2014). Generation of Antigenic Diversity in Plasmodium falciparum by Structured Rearrangement of Var Genes During Mitosis. [Data Collection]. PLOS Genetics. https://doi.org/10.1371/journal.pmed.1001893p://dx.doi.org/10.1371/journal.pmed.1001893

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Supplementary data for PLOS Genetics paper on the creation of antigenic diversity in Plasmodium falciparum through structured rearrangement of Var genes during mitosis.

Keywords

Genome sequence analysis, Plasmodium falciparum, Polymorphic gene family, Falciparum erythrocyte membrane protein, Var gene sequence, Var exon, Nucleotide sequence identity

Item Type	Data Collection
Capture method	Experiment: Laboratory
Date	18 December 2014
Language(s) of written materials	English
Creator(s)	Claessens, A, Hamilton, WL, Kekre, M, Otto, TD, Faizullabhoy, A, Rayner, JC and Kwiatkowski, D
LSHTM Faculty/Department	Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology (-2019)
Research Centre	Malaria Centre
Participating Institutions	Wellcome Trust Sanger Institute, University of Oxford, London School of Hygiene & Tropical Medicine
Funders	Project Funder Grant Number Funder URI UNSPECIFIED Wellcome Trust UNSPECIFIED http://dx.doi.org/10.13039/100010269 UNSPECIFIED Medical Research Council UNSPECIFIED http://dx.doi.org/10.13039/501100000265
Date Deposited	20 Oct 2015 09:51
Last Modified	20 Jan 2021 12:12
Publisher	PLOS Genetics

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Claessens, Antoine

Dept of Pathogen Molecular Biology (-2019)

Malaria Centre

Figshare (Other)
PLOS Genetics (Online Data Resource)

S1_Fig.pdf

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Generating clone trees
picture_as_pdf: application/pdf
folder_info: 782kB

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S1_Table.xlsx

subject: Data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Genome coverage for each subclone
grid_on: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
folder_info: 70kB

S2_Fig.pdf

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Chimeric var gene created by recombination
picture_as_pdf: application/pdf
folder_info: 336kB

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S2_Table.xlsx

subject: Data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: SNPs identified in clone trees
grid_on: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
folder_info: 69kB

S3_Fig.pdf

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Example of 7 recombination events within var gene exon2 in 3D7_1b
picture_as_pdf: application/pdf
folder_info: 967kB

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S3_Table.xlsx

subject: Data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Structural variants identified in the 3D7 clone tree, represented in Fig. 1
grid_on: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
folder_info: 141kB

S4_Fig.pdf

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Triple recombination event within less than 50 bp
picture_as_pdf: application/pdf
folder_info: 323kB

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S4_Table.xlsx

subject: Data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: All var gene recombinations
grid_on: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
folder_info: 96kB

S5_Fig.pdf

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Duplications in internal var gene clusters can also generate chimeras
picture_as_pdf: application/pdf
folder_info: 703kB

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S5_Table.xlsx

subject: Data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Mitotic point mutation rates and var gene recombination rates measured from clone trees
grid_on: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
folder_info: 55kB

S6_Fig.pdf

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Another example of internal var gene clusters generating chimeras
picture_as_pdf: application/pdf
folder_info: 602kB

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S6_Table.xlsx

subject: Data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Primers used for validating point mutations and var gene recombination by PCR amplification and capillary sequencing
grid_on: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
folder_info: 11kB

S7_Fig.pdf

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Evolution of a var gene
picture_as_pdf: application/pdf
folder_info: 583kB

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S7_Table.xlsx

subject: Data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Crosses progeny culture time and var gene recombinations
grid_on: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
folder_info: 38kB

S10_Fig.pdf

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Defining identity blocks. Var B/C genes recombine (A) ClustalW alignment of Dd2var34 and Dd2var45 at a crossover
picture_as_pdf: application/pdf
folder_info: 186kB

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S13_Fig.eps

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Distribution of var exon 1 recombination within each domain class
description: application/postscript
folder_info: 469kB

S14_Fig.eps

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: No recombination hotspot within DBL domains
description: application/postscript
folder_info: 181kB

S15_Fig.pdf

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: No conserved motifs within Identity Blocks.
picture_as_pdf: application/pdf
folder_info: 173kB

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S8_Fig.png

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: All var exon 1 translocations identified in this study
image: image/png
folder_info: 4MB

S9_Fig.png

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Group B/C var genes do not necessarily recombine with var genes of highest similarity
image: image/png
folder_info: 2MB

S11_Fig.png

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Recombination in var genes occurs where sequences are similar
image: image/png
folder_info: 1MB

S12_Fig.png

subject: Graphical representation of data
Creative Commons: Attribution: Available under Creative Commons: Attribution 3.0
info: Var gene exon 1 recombine in short regions of higher homology
image: image/png
folder_info: 4MB

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