Plasma biomarker data from the FIEBRE-Mozambique Cohort
Balanza, N; Bassat, Q; Kain, KC; Hopkins, H
; Mabey, DC and Lal, S
(2025).
Plasma biomarker data from the FIEBRE-Mozambique Cohort.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00004583.
; Mabey, DC and Lal, S
(2025).
Plasma biomarker data from the FIEBRE-Mozambique Cohort.
[Dataset].
London School of Hygiene & Tropical Medicine, London, United Kingdom.
10.17037/DATA.00004583.
An anonymised dataset of 1,955 paediatric and adult patients with febrile illness in southern Mozambique, who gave informed consent to participate in the prospective observational FIEBRE study between December 2018 and February 2021. Dataset contains variables on biomarker levels in plasma, demographic data, results of basic diagnostic tests and health status data, calculated clinical severity scores, and mortality and other adverse outcomes by day 28 follow-up.
Keywords
Biomarkers; Fever; Prognosis; Mortality; Risk stratification| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Description of data capture | Study staff collected demographic data, took a standardised clinical history, and performed a physical examination. Lactate levels was measured on-site with a point-of-care analyser. Additional clinical data were collected for inpatients during admission and at discharge. In a follow-up visit at day 28, vital status and data related to the original illness episode were documented. All data were recorded electronically using Open Data Kit (ODK). Plasma samples were analysed at UHN (Toronto, Canada) for biomarkers of immune and endothelial activation using Luminex and ELISA, and the biomarker results were merged with the rest of the dataset using study IDs. Data cleaning involved consistency checks and verifying data integrity to ensure accuracy before statistical analysis and sharing. For biomarker data, duplicate measurements were averaged and concentrations outside the dynamic range were assigned the highest limit of the standard curve or a value of one-third of the lowest limit. |
| Capture method | Physical measurements and tests |
| Collection Period |
From To December 2018 March 2021 |
| Date | 24 February 2025 |
| Language(s) of written materials | English |
| Creator(s) |
Balanza, N; Bassat, Q; Kain, KC; Hopkins, H; Mabey, DC and Lal, S
|
| LSHTM Faculty/Department |
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research Faculty of Infectious and Tropical Diseases > Dept of Disease Control |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Funders |
Project Funder Grant Number Funder URI Febrile Illness Evaluation in a Broad Range of Endemicities (FIEBRE) Study Consortium UNSPECIFIED https://doi.org/10.13039/501100020171 |
| Date Deposited | 24 Feb 2025 15:38 |
| Last Modified | 07 Aug 2025 15:34 |
| Publisher | London School of Hygiene & Tropical Medicine |
Data / Code
FIEBRE_biomarkers_data.csv
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subject - Data
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lock - Restricted to Request access for all
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copyright - Available under Data Sharing Agreement
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info - A dataset of 1,955 febrile patients in Mozambique from the FIEBRE study, including plasma biomarker levels, clinical data, and outcomes by day 28
description - text/plain
- folder_info
- 53B
Documentation
FIEBRE_biomarkers_data_codebook.html
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subject - Documentation
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- Available under Creative Commons: Attribution 4.0
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info - Codebook for FIEBRE biomarkers data
html - text/html
- folder_info
- 11kB
4583_UserGuide.html
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subject - Documentation
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- Available under Creative Commons: Attribution 4.0
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info - User guide for FIEBRE biomarkers data
html - text/html
- folder_info
- 7kB
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