Genetic predisposition to ductal carcinoma in situ of the breast

Petridis, C, Brook, MN, Shah, V, Kohut, K, Gorman, P, Caneppele, M, Levi, D, Papouli, E, Orr, N, Cox, A, Cross, SS, Dos santos silva, I, Peto, J, Swerdlow, A, Schoemaker, MJ, Bolla, MK, Wang, Q, Dennis, J, Michailidou, K, Benitez, J, González-Neira, A, Tessier, DC, Vincent, D, Li, J, Figueroa, J, Kristensen, V, Borresen-Dale, A, Soucy, P, Simard, J, Milne, RL, Giles, GG, Margolin, S, Lindblom, A, Brüning, T, Brauch, H, Southey, MC, Hopper, JL, Dörk, T, Bogdanova, NV, Kabisch, M, Hamann, U, Schmutzler, RK, Meindl, A, Brenner, H, Arndt, V, Winqvist, R, Pylkäs, K, Fasching, PA, Beckmann, MW, Lubinski, J, Jakubowska, A, Mulligan, AM, Andrulis, IL, Tollenaar, Rob A. E. M., Devilee, P, Le Marchand, L, Haiman, CA, Mannermaa, A, Kosma, V, Radice, P, Peterlongo, P, Marme, F, Burwinkel, B, van Deurzen, CHM, Hollestelle, A, Miller, N, Kerin, MJ, Lambrechts, D, Floris, G, Wesseling, J, Flyger, H, Bojesen, SE, Yao, S, Ambrosone, CB, Chenevix-Trench, G, Truong, T, Guénel, P, Rudolph, A, Chang-Claude, J, Nevanlinna, H, Blomqvist, C, Czene, K, Brand, JS, Olson, JE, Couch, FJ, Dunning, AM, Hall, P, Easton, DF, Pharoah, PDP, Pinder, SE, Schmidt, MK, Tomlinson, I, Roylance, R, García-Closas, M and Sawyer, EJ. 2016. Genetic predisposition to ductal carcinoma in situ of the breast. [Online]. Breast Cancer Research. Available from: https://doi.org/10.1186/s13058-016-0675-7.

Petridis, C, Brook, MN, Shah, V, Kohut, K, Gorman, P, Caneppele, M, Levi, D, Papouli, E, Orr, N, Cox, A, Cross, SS, Dos santos silva, I, Peto, J, Swerdlow, A, Schoemaker, MJ, Bolla, MK, Wang, Q, Dennis, J, Michailidou, K, Benitez, J, González-Neira, A, Tessier, DC, Vincent, D, Li, J, Figueroa, J, Kristensen, V, Borresen-Dale, A, Soucy, P, Simard, J, Milne, RL, Giles, GG, Margolin, S, Lindblom, A, Brüning, T, Brauch, H, Southey, MC, Hopper, JL, Dörk, T, Bogdanova, NV, Kabisch, M, Hamann, U, Schmutzler, RK, Meindl, A, Brenner, H, Arndt, V, Winqvist, R, Pylkäs, K, Fasching, PA, Beckmann, MW, Lubinski, J, Jakubowska, A, Mulligan, AM, Andrulis, IL, Tollenaar, Rob A. E. M., Devilee, P, Le Marchand, L, Haiman, CA, Mannermaa, A, Kosma, V, Radice, P, Peterlongo, P, Marme, F, Burwinkel, B, van Deurzen, CHM, Hollestelle, A, Miller, N, Kerin, MJ, Lambrechts, D, Floris, G, Wesseling, J, Flyger, H, Bojesen, SE, Yao, S, Ambrosone, CB, Chenevix-Trench, G, Truong, T, Guénel, P, Rudolph, A, Chang-Claude, J, Nevanlinna, H, Blomqvist, C, Czene, K, Brand, JS, Olson, JE, Couch, FJ, Dunning, AM, Hall, P, Easton, DF, Pharoah, PDP, Pinder, SE, Schmidt, MK, Tomlinson, I, Roylance, R, García-Closas, M and Sawyer, EJ. Genetic predisposition to ductal carcinoma in situ of the breast. [Internet] LSHTM Data Compass. Breast Cancer Research; 2016. Available from: https://doi.org/10.1186/s13058-016-0675-7.

Petridis, C, Brook, MN, Shah, V, Kohut, K, Gorman, P, Caneppele, M, Levi, D, Papouli, E, Orr, N, Cox, A, Cross, SS, Dos santos silva, I, Peto, J, Swerdlow, A, Schoemaker, MJ, Bolla, MK, Wang, Q, Dennis, J, Michailidou, K, Benitez, J, González-Neira, A, Tessier, DC, Vincent, D, Li, J, Figueroa, J, Kristensen, V, Borresen-Dale, A, Soucy, P, Simard, J, Milne, RL, Giles, GG, Margolin, S, Lindblom, A, Brüning, T, Brauch, H, Southey, MC, Hopper, JL, Dörk, T, Bogdanova, NV, Kabisch, M, Hamann, U, Schmutzler, RK, Meindl, A, Brenner, H, Arndt, V, Winqvist, R, Pylkäs, K, Fasching, PA, Beckmann, MW, Lubinski, J, Jakubowska, A, Mulligan, AM, Andrulis, IL, Tollenaar, Rob A. E. M., Devilee, P, Le Marchand, L, Haiman, CA, Mannermaa, A, Kosma, V, Radice, P, Peterlongo, P, Marme, F, Burwinkel, B, van Deurzen, CHM, Hollestelle, A, Miller, N, Kerin, MJ, Lambrechts, D, Floris, G, Wesseling, J, Flyger, H, Bojesen, SE, Yao, S, Ambrosone, CB, Chenevix-Trench, G, Truong, T, Guénel, P, Rudolph, A, Chang-Claude, J, Nevanlinna, H, Blomqvist, C, Czene, K, Brand, JS, Olson, JE, Couch, FJ, Dunning, AM, Hall, P, Easton, DF, Pharoah, PDP, Pinder, SE, Schmidt, MK, Tomlinson, I, Roylance, R, García-Closas, M and Sawyer, EJ (2016). Genetic predisposition to ductal carcinoma in situ of the breast. [Data Collection]. Breast Cancer Research. https://doi.org/10.1186/s13058-016-0675-7.

Description

Data capture method Aggregation
Date (Published in a 3rd party system) 17 February 2016
Language(s) of written materials English
Data Creators Petridis, C, Brook, MN, Shah, V, Kohut, K, Gorman, P, Caneppele, M, Levi, D, Papouli, E, Orr, N, Cox, A, Cross, SS, Dos santos silva, I, Peto, J, Swerdlow, A, Schoemaker, MJ, Bolla, MK, Wang, Q, Dennis, J, Michailidou, K, Benitez, J, González-Neira, A, Tessier, DC, Vincent, D, Li, J, Figueroa, J, Kristensen, V, Borresen-Dale, A, Soucy, P, Simard, J, Milne, RL, Giles, GG, Margolin, S, Lindblom, A, Brüning, T, Brauch, H, Southey, MC, Hopper, JL, Dörk, T, Bogdanova, NV, Kabisch, M, Hamann, U, Schmutzler, RK, Meindl, A, Brenner, H, Arndt, V, Winqvist, R, Pylkäs, K, Fasching, PA, Beckmann, MW, Lubinski, J, Jakubowska, A, Mulligan, AM, Andrulis, IL, Tollenaar, Rob A. E. M., Devilee, P, Le Marchand, L, Haiman, CA, Mannermaa, A, Kosma, V, Radice, P, Peterlongo, P, Marme, F, Burwinkel, B, van Deurzen, CHM, Hollestelle, A, Miller, N, Kerin, MJ, Lambrechts, D, Floris, G, Wesseling, J, Flyger, H, Bojesen, SE, Yao, S, Ambrosone, CB, Chenevix-Trench, G, Truong, T, Guénel, P, Rudolph, A, Chang-Claude, J, Nevanlinna, H, Blomqvist, C, Czene, K, Brand, JS, Olson, JE, Couch, FJ, Dunning, AM, Hall, P, Easton, DF, Pharoah, PDP, Pinder, SE, Schmidt, MK, Tomlinson, I, Roylance, R, García-Closas, M and Sawyer, EJ
LSHTM Faculty/Department Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Participating Institutions Study consortium
Funders
ProjectFunderGrant NumberFunder URI
UNSPECIFIEDBreast Cancer NowUNSPECIFIEDUNSPECIFIED
Depositor LSHTM Library & Archives Service
Date Deposited 25 Feb 2016 10:43
Last Modified 05 Aug 2016 15:30
Publisher Breast Cancer Research

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Filename: AdditionalFile-01_MSWord.docx

Description: Study information for the Breast Cancer Association Consortium ( BCAC ) participating studies

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Filename: AdditionalFile-02_MSWord.docx

Description: Sample information for the SEARCH, UKBGS, SBCS, and BBCS studies

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Filename: AdditionalFile-03_Excel.xlsx

Description: Number of studies and individuals included in analyses of ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC)

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File size: 13kB

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Filename: AdditionalFile-06_MSWord.docx

Description: Grade, estrogen receptor (ER) status, and age groups in patients with ductal carcinoma in situ (DCIS)

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Filename: AdditionalFile-07_Excel.xlsx

Description: Association between ductal carcinoma in situ (DCIS) and known breast cancer predisposition loci.IDC invasive ductal carcinoma, P-Het P value for heterogeneity, SNP single nucleotide polymorphism, OR odds ratio

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File size: 20kB

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Filename: AdditionalFile-08_Excel.xlsx

Description: Age-specific case-only analysis of patients with ductal carcinoma in situ (DCIS) diagnosed at age <50 vs ≥50 years.P-Het P value for heterogeneity, SNP single nucleotide polymorphism, OR odds ratio

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File size: 17kB

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Filename: AdditionalFile-09_Excel.xlsx

Description: Associations between the known breast cancer predisposition loci and estrogen receptor-positive (ER+) or ER– ductal carcinoma in situ (DCIS) .P-Het P value for heterogeneity, SNP single nucleotide polymorphism, OR odds ratio

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File size: 19kB

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Filename: AdditionalFile-11_Excel.xlsx

Description: Associations of the known breast cancer predisposition loci for high and low-intermediate grade ductal carcinoma in situ (DCIS) .P-Het P value for heterogeneity, OR odds ratio

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File size: 19kB

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Filename: AdditionalFile-12_Excel.xlsx

Description: Association of rs75915166 and rs554219 with grade in invasive ductal carcinoma ( IDC ).P-Het P value for heterogeneity, OR odds ratio

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File size: 9kB

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Filename: AdditionalFile-13_Excel.xlsx

Description: Associations between the known and novel breast cancer predisposition loci and invasive ductal cancer, by estrogen receptor ( ER ) status and grade.OR odds ratio

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File size: 25kB

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Filename: AdditionalFile-14_Excel.xlsx

Description: Association between the known breast cancer predisposition loci and estrogen receptor-positive (ER+) ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS) .P-Het P value for heterogeneity, SNP single nucleotide polymorphism, OR odds ratio

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Data Visualisation

Filename: AdditionalFile-04_PDF.pdf

Description: Principal component analysis (PCA) results from the study to investigate the genetics of in situ carcinoma of the ductal subtype (ICICLE)

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File size: 258kB

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Filename: AdditionalFile-05_PDF.pdf

Description: Quantile-quantile plots from the study to investigate the genetics of in situ carcinoma of the ductal subtype (ICICLE ).SNP single nucleotide polymorphism

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File size: 204kB

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Filename: AdditionalFile-10a-PDF.pdf

Description: Known breast cancer predisposition loci for low/intermediate grade (black) and high grade ductal carcinoma in situ (DCIS) (gray)

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File size: 14kB

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Filename: AdditionalFile-10b-PDF.pdf

Description: Due to the large number of single nucleotide polymorphisms (SNPs), the plot is split for better visual representation into two different sections (a and b) with a descending order of effect size for the low/intermediate group. OR odds ratio

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