S1 Data for: "A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia"
James, P
; Jawla, O; Mohammed, N; Ceesay, K; Akemokwe, F; Sonko, B; Sise, E; Prentice, A and Silver, M
(2019).
S1 Data for: "A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia".
[Dataset].
PLOS Medicine.
https://doi.org/10.1371/journal.pmed.1002870.s007
; Jawla, O; Mohammed, N; Ceesay, K; Akemokwe, F; Sonko, B; Sise, E; Prentice, A and Silver, M
(2019).
S1 Data for: "A novel nutritional supplement to reduce plasma homocysteine in nonpregnant women: A randomised controlled trial in The Gambia".
[Dataset].
PLOS Medicine.
https://doi.org/10.1371/journal.pmed.1002870.s007
Infant DNA methylation profiles are associated with their mother’s periconceptional nutritional status. DNA methylation relies on nutritional inputs for one-carbon metabolic pathways, including the efficient recycling of homocysteine. This randomised controlled trial in nonpregnant women in rural Gambia tests the efficacy of a novel nutritional supplement designed to improve one-carbon-related nutrient status by reducing plasma homocysteine, and assesses its potential future use in preconception trials.
Keywords
plasma homocysteine; DNA methylation profiles; Pregnancy; Metabolic pathways; Blood plasma; DNA methylation; Folic acid; Blood pressure; B vitamins; United Nations| Item Type | Dataset |
|---|---|
| Resource Type |
Resource Type Resource Description Dataset Quantitative |
| Capture method | Experiment |
| Date | 13 August 2019 |
| Language(s) of written materials | English |
| Creator(s) |
James, P; Jawla, O; Mohammed, N; Ceesay, K; Akemokwe, F; Sonko, B; Sise, E; Prentice, A and Silver, M
|
| LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) MRC Unit The Gambia at LSHTM > GM-Disease Control and Elimination Theme MRC Unit The Gambia at LSHTM > GM-Nutrition Theme |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
| Date Deposited | 22 Aug 2019 15:27 |
| Last Modified | 26 Jun 2025 09:38 |
| Publisher | PLOS Medicine |
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