Expression data from Gambian children with and without the clinical signs of active trachoma: U133 Plus2.0 array

Natividad, A, Freeman, TC, Jeffries, D, Burton, MJ, Mabey, DCW, Bailey, RL and Holland, MJ. 2010. Expression data from Gambian children with and without the clinical signs of active trachoma: U133 Plus2.0 array. [Online]. NCBI Gene Expression Omnibus. Available from: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE20436

Natividad, A, Freeman, TC, Jeffries, D, Burton, MJ, Mabey, DCW, Bailey, RL and Holland, MJ. Expression data from Gambian children with and without the clinical signs of active trachoma: U133 Plus2.0 array. [Internet] LSHTM Data Compass. NCBI Gene Expression Omnibus; 2010. Available from: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE20436

Natividad, A, Freeman, TC, Jeffries, D, Burton, MJ, Mabey, DCW, Bailey, RL and Holland, MJ (2010). Expression data from Gambian children with and without the clinical signs of active trachoma: U133 Plus2.0 array. [Data Collection]. NCBI Gene Expression Omnibus. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE20436

Description

Description of data capture Conjunctival samples from 60 participants were tested on U133 plus 2.0 arrays (40 participants with clinical signs of active trachoma and 20 controls with normal conjunctivas as before). Samples were further sub-divided based on the detection and quantification of ocular Chlamydia trachomatis load by PCR tests. Gene expression was then assessed using differential expression and construction of co-expression networks. The content of the constructed gene lists which were identified as part of a network or differentially expressed were then tested for enrichment using publically available analysis tools to identify biological pathways expressed in the conjunctiva during C. trachomatis infection and disease episodes.
Data capture method Experiment
Date (Published in a 3rd party system) 3 September 2010
Language(s) of written materials English
Data Creators Natividad, A, Freeman, TC, Jeffries, D, Burton, MJ, Mabey, DCW, Bailey, RL and Holland, MJ
LSHTM Faculty/Department Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Participating Institutions London School of Hygiene & Tropical Medicine, London, United Kingdom
Depositor Gareth Knight
Date Deposited 11 Jan 2019 10:20
Last Modified 11 Jan 2019 10:31
Publisher NCBI Gene Expression Omnibus

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