Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda

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Lule, SA, Mawa, P, Nkurunungi, G, Nampijja, M, Kizito, D, Akello, F, Muhangi, L, Elliott, A and Webb, EL. 2014. Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda. [Online]. Vaccine. Available from: 10.1016/j.vaccine.2014.12.015

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BCG is used widely as the sole licensed vaccine against tuberculosis, but it has variable efficacy and the reasons for this are still unclear. No reliable biomarkers to predict future protection against, or acquisition of, TB infection following immunisation have been identified. Lessons from BCG could be valuable in the development of effective tuberculosis vaccines. The Entebbe Mother and Baby Study birth cohort in Uganda investigated factors associated with latent tuberculosis infection (LTBI) and with cytokine response to mycobacterial antigen at age five years. It also investigated whether cytokine responses at one year were associated with LTBI at five years of age. This dataset contains tabular data associated with the analysis

Published in a 3rd party system Date: 19 December 2014
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Experiment: Field Intervention
Data Creators(s): Lule, SA, Mawa, P, Nkurunungi, G, Nampijja, M, Kizito, D, Akello, F, Muhangi, L, Elliott, A and Webb, EL
LSHTM Faculty/Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Participating Institutions: MRC/UVRI Uganda Research Unit on AIDS, Entebbe Hospital, Uganda, London School of Hygiene & Tropical Medicine

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