Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result"

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Hanifa, Y, Fielding, K, Grant, AD and Churchyard, GJ. 2016. Data for: "The utility of repeat Xpert MTB/RIF testing to diagnose tuberculosis in HIV-positive adults with initial negative result". [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: 10.17037/DATA.284

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The World Health Organization recommends regular tuberculosis screening of HIV-positive individuals with Xpert MTB/RIF as the first diagnostic test. Further evaluation of those who are HIV-positive and Xpert-negative comprises clinical reassessment, chest radiograph (if available), sputum for mycobacterial culture, and treatment with antibiotic if clinically indicated. The aim of our study was to describe the diagnostic yield from an immediate repeat sputum tested with Xpert, compared to sequential further investigation guided by South African recommendations , amongst HIV-positive adults in South Africa being investigated for TB whose initial sputum Xpert result is negative. It was a sub-study of “Xpert for people attending HIV/AIDS care: test or review?” (XPHACTOR), a prospective cohort study evaluating a risk-based algorithm to prioritise Xpert testing amongst adults attending for routine HIV care in South Africa. This dataset contains data for 227 adults attending for routine HIV care who have an initial negative sputum Xpert result. It includes basic demographics, TB diagnoses, mycobacteriology and chest radiograph results. Data was collected for the purpose of HIV and TB research and can only be reused for related research, in accordance with the participant consent agreement.

Completed Date: August 2016
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Mode of data capture
Interview: Face-to-face
Questionnaire: Fixed form - Paper
Data Creators(s): Hanifa, Y, Fielding, K, Grant, AD and Churchyard, GJ
Associated roles: Hanifa, Y (Co-Investigator), Fielding, K (Co-Investigator), Chihota, VN (Co-Investigator), Adonis, L (Co-Investigator), Charalambous, S (Co-Investigator), Foster, N (Co-Investigator), Karstaedt, A (Co-Investigator), McCarthy, K (Co-Investigator), Nicol, MP (Co-Investigator), Ndlovu, NT (Project Manager), Sinanovic, E (Co-Investigator), Sahid, F (Other), Stevens, W (Co-Investigator), Vassall, A (Co-Investigator), Churchyard, GJ (Principal Investigator) and Grant, AD (Principal Investigator)
LSHTM Faculty/Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: TB Centre
Participating Institutions: TB Centre, London School of Hygiene & Tropical Medicine, London, United Kingdom, The Aurum Institute, South Africa, National Health Laboratory Services, South Africa, University of Cape Town, South Africa

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