Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors

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Sheehy, SH, Duncan, CJA, Elias, SC, Biswas, S, Collins, KA, O'hara, G, Halstead, FD, Ewer, KJ, Mahungu, T, Spencer, AJ, Miura, K, Poulton, ID, Dicks, MDJ, Edwards, NJ, Berrie, E, Moyle, S, Colloca, S, Cortese, R, Gantlett, K, Long, CA, Lawrie, AM, Gilbert, SC, Doherty, T, Nicosia, A, Hill, AVS and Draper, SJ. 2012. Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors. [Online]. Figshare Digital Repository. Available from: 10.17037/DATA.24 http://dx.doi.org/10.1371/journal.pone.0031208

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Traditionally, vaccine development against the blood-stage of Plasmodium falciparum infection has focused on recombinant protein-adjuvant formulations in order to induce high-titer growth-inhibitory antibody responses. However, to date no such vaccine encoding a blood-stage antigen(s) alone has induced significant protective efficacy against erythrocytic-stage infection in a pre-specified primary endpoint of a Phase IIa/b clinical trial designed to assess vaccine efficacy. Cell-mediated responses, acting in conjunction with functional antibodies, may be necessary for immunity against blood-stage P. falciparum. The development of a vaccine that could induce both cell-mediated and humoral immune responses would enable important proof-of-concept efficacy studies to be undertaken to address this question.

Published in a 3rd party system Date: 21 February 2012
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Experiment: Laboratory
Data Creators(s): Sheehy, SH, Duncan, CJA, Elias, SC, Biswas, S, Collins, KA, O'hara, G, Halstead, FD, Ewer, KJ, Mahungu, T, Spencer, AJ, Miura, K, Poulton, ID, Dicks, MDJ, Edwards, NJ, Berrie, E, Moyle, S, Colloca, S, Cortese, R, Gantlett, K, Long, CA, Lawrie, AM, Gilbert, SC, Doherty, T, Nicosia, A, Hill, AVS and Draper, SJ
LSHTM Faculty/Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Participating Institutions: London School of Hygiene & Tropical Medicine

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