Zhao, X, Yuan, Y, Lin, Y, Zhang, T, Bai, Y, Kang, D, Li, X, Kang, W, Dlodlo, RA and Harries, AD. 2018. S1 File for "Vitamin D status of tuberculosis patients with diabetes mellitus in different economic areas and associated factors in China". [Online]. PLOS One. Available from: https://doi.org/10.1371/journal.pone.0206372.s001
Zhao, X, Yuan, Y, Lin, Y, Zhang, T, Bai, Y, Kang, D, Li, X, Kang, W, Dlodlo, RA and Harries, AD. S1 File for "Vitamin D status of tuberculosis patients with diabetes mellitus in different economic areas and associated factors in China" [Internet]. PLOS One; 2018. Available from: https://doi.org/10.1371/journal.pone.0206372.s001
Zhao, X, Yuan, Y, Lin, Y, Zhang, T, Bai, Y, Kang, D, Li, X, Kang, W, Dlodlo, RA and Harries, AD (2018). S1 File for "Vitamin D status of tuberculosis patients with diabetes mellitus in different economic areas and associated factors in China". [Data Collection]. PLOS One. https://doi.org/10.1371/journal.pone.0206372.s001
Description
Vitamin D could be a mediator in the association between tuberculosis (TB) and diabetes mellitus (DM). A large scale multi-center study confirmed that TB patients with DM had significantly lower serum vitamin D level compared with those without DM and reported that DM was a strong independent risk factor for vitamin D deficiency. This study was undertaken to determine amongst patients with both TB and DM living in different economically defined areas in China: i) their baseline characteristics, ii) their vitamin D status and iii) whether certain baseline characteristics were associated with vitamin D deficiency. In DM-TB patients consecutively attending seven clinics or hospitals, we measured 25 hydroxycholecalciferol at the time of registration using electrochemiluminescence in a COBASE 601 Roche analyser by chemiluminescence immunoassay. Data analysis was performed using chi square test and multivariate logistic regression. There were 178 DM-TB patients that included 50 from economically well-developed areas, 103 from better-off areas and 25 from a poverty area. Median vitamin D levels in well-developed, better-off and poverty areas were 11.5ng/ml, 12.2ng/ml and 11.5ng/ml respectively. Amongst all patients, 149 (84%) had vitamin D deficiency-91 (51%) with vitamin D deficiency (10-19.9 ng/ml) and 58 (33%) with severe deficiency (< 10 ng/ml). There was a significantly higher proportion with vitamin D deficiency in the poverty area. The adjusted odds of vitamin D deficiency (25-(OH)D3 <20 ng/ml) were significantly higher in those with longer history of DM (P = 0.038) and with HbA1c≥10% (P = 0.003). Over 80% of TB patients with DM in China were vitamin D deficient, with risk factors being residence in a poverty area, a long duration of DM and uncontrolled DM. TB programme managers and clinicians need to pay more attention to the vitamin D status of their patients.
Data capture method | Questionnaire | ||||||||||||
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Date (Date published in a 3rd party system) | 1 November 2018 | ||||||||||||
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Language(s) of written materials | English |
Data Creators | Zhao, X, Yuan, Y, Lin, Y, Zhang, T, Bai, Y, Kang, D, Li, X, Kang, W, Dlodlo, RA and Harries, AD |
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LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
Date Deposited | 06 Nov 2018 11:50 |
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Last Modified | 20 Jan 2021 10:46 |
Publisher | PLOS One |