Cox, S, Makani, J, Lee, N and Sangeda, R. 2018. Dataset for: Hepcidin in Tanzanian children with sickle cell disease. [Online]. London School of Hygiene & Tropical Medicine, London, United Kingdom. Available from: https://doi.org/10.17037/DATA.00000781.
Cox, S, Makani, J, Lee, N and Sangeda, R. Dataset for: Hepcidin in Tanzanian children with sickle cell disease [Internet]. London School of Hygiene & Tropical Medicine; 2018. Available from: https://doi.org/10.17037/DATA.00000781.
Cox, S, Makani, J, Lee, N and Sangeda, R (2018). Dataset for: Hepcidin in Tanzanian children with sickle cell disease. [Data Collection]. London School of Hygiene & Tropical Medicine, London, United Kingdom. https://doi.org/10.17037/DATA.00000781.
Description
An anonymised dataset of 199 pediatric patients aged 3-18 years of age, enrolled in the prospective Muhimbili Sickle Cohort (MSC), (Makani et al. PloS ONE 2011), whose parent or guardian consented to participate, which included having blood and DNA samples archived for studies relating to understanding the pathophysiology of sickle cell disease in Tanzanian patients. The dataset contains variables on age, sex, sickle phenotype (derived from electrophoresis and high performance liquid chromatography), history of previous blood transfusion and averaged steady state hemoglobin concentrations over the previous year prior to the samples included in this analysis. Samples included in this analysis were collected at scheduled routine clinic visits at which children were assessed by the attending physician as “clinically well” with no current pain, no fever and were malaria test (smear and or rapid test) negative, and had no reported or recorded hospitalization in the previous month. Laboratory data from the analysed samples include complete blood count data, clinical chemistry values, inflammatory markers, iron markers, erythropoietin and hepcidin. Alpha thalassaemia 3.7 deletion and glucose-6-phosphate dehydrogenase deficiency as potentially disease modifying genotypes are also included.
Keywords
Description of data capture | Please see details in associated manuscript: Lee et al. Decreased hepcidin levels are associated with low steady-state hemoglobin in children with sickle cell disease in Tanzania. EBioMed 2018. | ||||||||
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Data capture method | Questionnaire | ||||||||
Data Collection Period |
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Date (Date submitted to LSHTM repository) | 17 July 2018 | ||||||||
Geographical area covered (offline during plugin upgrade) |
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Language(s) of written materials | English |
Data Creators | Cox, S, Makani, J, Lee, N and Sangeda, R |
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LSHTM Faculty/Department | Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) |
Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom, Muhimbili University of Health & Allied Sciences, Dar es Salaam, Tanzania |
Funders |
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Date Deposited | 20 Aug 2018 17:04 |
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Last Modified | 27 Apr 2022 18:19 |
Publisher | London School of Hygiene & Tropical Medicine |
Downloads
Data / Code
Restricted to: Request access for all
Filename: Hepcidin_dataset.csv
Description: Hepcidin dataset - CSV and Excel format
Licence: Data Sharing Agreement
Content type: Dataset
File size: 29B
Mime-Type: text/plain
Documentation
Filename: Codebook.html
Description: Dataset codebook for manuscript Lee et al EBioMed 2018
Content type: Textual content
File size: 12kB
Mime-Type: text/html
Filename: scd_information_sheet.pdf
Description: Consent form and informed sheet
Content type: Textual content
File size: 290kB
Mime-Type: application/pdf