Dataset for Hepcidin in Tanzanian children with sickle cell disease - Codebook

Codebook for dataset located at https:doi.org/10.17037/DATA.00000781

Variable Data type derived variable? No of observations Description Variable contains blank/missing values Reason for missing values Value coding
age_mcv ordered categorical yes 269 age category on day of blood sample analysed - used for derived variable of microcytic No Not applicable 0 = "0-2yr"
1 = "2-5yr"
2 = "6-10"
3 = "11-14yr"
4 = "15-74 yr"
agehplc continuous no 232 age on date of hplc assessment of HbF Yes Only available for those who had HbF measured by HPLC  
agetod_integer integer no 269 age on date of blood sample analysed in whole years No Not applicable  
agp_high binary yes 266 AGP >= 120 mg\dL Yes not able to be assessed in all samples 0=<120 mg\dL
1=>=120mg\dL
agp_mgdl continuous no 266 Serum AGP in mg\dL Yes not able to be assessed in all samples  
athal ordered categorical no 238 Alpha-Thalassemia genotype - no of copies of 3.7 deletion - Yes not available for all participants 0 ="Wild Type"
1=" -/a a/a"
2= "-/a -/a"
bilirubin_lysis continuous no 248 Indirect bilirubin (umol/L) Yes not able to be assessed in all samples  
bilirubind continuous no 258 Direct bilirubin (umol/L) Yes not able to be assessed in all samples  
bilirubint continuous no 258 Total bilirubin (umol/L) Yes not able to be assessed in all samples  
crp_high binary yes 266 CRP >= 5mg/L Yes not able to be assessed in all samples 0=<5mg/L
1=>=5mg/L
crp_mgL continuous no 266 Serum crp in mg/L Yes not able to be assessed in all samples  
datetod date no 269 date of sample analysed and of complete blood count data - including hgb, wbc, mcv mchc mch, reticulocyte where available and 02 saturation no    
diffdays integer yes 107 Number of days between nearest recorded admission to Muhimbili National Hospital and sample date yes not all children had admissions  
epo continuous no 241 Serum erythriopoietin (uIU/mL) yes not able to be assessed in all samples  
epo_ln continuous yes 241 Natural log of erythropoeitin continuos variable yes not able to be assessed in all samples  
ferritin_ln continuous yes 266 Natural log of ferritin variable yes    
ferritin_ugL continuous no 266 Serum ferritin in ug/L yes not able to be assessed in all samples  
g6pd ordered categorical no 216 G6PD status based on A- genotype [-202 & 376 SNPS} yes not available in all children 0 = "Normal"
1 = "Homozygous Female"
2 = "Homozygous Male or Female"
hbf_final continuous yes 228 Fetal haemoglobin (%), excluding those who had s (HbF at <
age 5 years & hepcidin sample >age 5 years)
yes not available in all children or meeting criteria  
hep continuous no 255 Serum hepcidin (ng/mL) yes not able to be assessed in all samples  
hep_eii binary yes 255 hepcidin < 5.5 ng/ml yes not able to be assessed in all samples 1 if <5.5 ng/mL
"0" if >5.5 ng/mL
hep_ln continuous yes 255 Natural log of hepcidin continuous variable yes not able to be assessed in all samples  
hgb continuous no 264 Haemoglobin on day of sample yes missing from source database  
hgbssv continuous yes 269 Averaged Haemoglobin (g\dL) at steady state routine clinic visits no Not applicable
hgbssv_OR binary yes 269 Categorical variable used in logistic regression
highest or lowest quartile of averaged steady -state haemoglobin
no See associated publication Lee et al for more details 0=highest quartile
1=lowest quartile
hyperfe binary yes 269 Hyperferremia (>70 ug/L) if inflammation is normal ( if CRP<5g/L and AGP <120 mg\dL) yes not able to be assessed in all samples 0=normal or low
1=high ferritin
hypofe binary yes 266 Hypoferremia < 30g/L yes not able to be assessed in all samples 0 =Ferritin>=30g/L
1 =Ferritin< 30g/L
id integer no 269 unique participant identifier - linked through separate linkage file to demographic_id, the unique study ID of all participants in Muhimbili Sickle Cohort and associated databases no    
inflammation binary yes 266 presence of inflammation: CRP>5g/L or AGP>120 mg\dL yes not able to be assessed in all samples 0=CRP<5g/L & AGP<120mg\dL
1=CRP>=5mg/L OR AGP>=120mg\dL
iron_umoll continuous no 264 serum iron in ummol/L yes not able to be assessed in all samples  
ldh continuous no 190 Lactate Dehydrogenase (IU/L) yes not available for all participants  
mch continuous no 264 Mean cell haemoglobin concentration (g\dL) yes missing from source database  
mchc continuous no 264 Mean cell haemoglobin concentration (g\dL) yes missing from source database  
mcv continuous yes 260 Mean cell volume (fL/cell) yes missing from source database  
microcytic binary yes 264 microcytic Yes/No with age-specific MCV cut-offs  Cut-offs for MCV (fL) were MCV <75 if age 1&ndash3 years,, MCV b<79 if aged 3&ndash
5 years, MCV <80 if age 6&ndash11 years, MCV <
82 if age 11-14 years, MCV <85 if aged 15&ndash74 years
yes source data missing from source database 0= normal
1=microcytic
reticulocyte continuous no 151 Reticuloctye percentage on day of smple analysis yes missing from source database (technique not performed on all samples at all times)  
sat continuous no 217 Oxygen saturation (Room Air) pulse oximetry on day of sample analysed yes missing from source database  
sex binary   269 Sex of participant no Not applicable 0= Female
1=Male
stfr_F_def binary yes 259  
possible Iron deficient by sTfR-Ferritin index [Phiri et al 2009 J Clinical Pathology]
yes not able to be assessed in all samples 0 = "sTfR-F index <5.6"
1 = "sTfR-F index => 5.6"
stfr_F_index continuous yes 259 Calculated by the function [sTfR[ug/mL]/ln(ferritin)] yes not able to be assessed in all samples  
stfr_ugml continuous no 259 Serum transferrin receptor (ug/mL) yes not able to be assessed in all samples  
tfr_mgdl continuous no   Transferrin (mg\dL)   not able to be assessed in all samples  
tibc continuous no 266 Total Iron Binding Capacity (umol/L) yes not able to be assessed in all samples  
transferrin_gl continuous no   Serum transferrin in g/L   not able to be assessed in all samples  
trf_sat continuous no   Transferrin saturation calculated as [(serum iron conc/TIBC)*100]   not able to be assessed in all samples  
trf_sat_def binary yes   Categorical variable of Transferrin saturation   not able to be assessed in all samples 0 = ">15%"
1 "=< 16%"
visitno integer no    
sample analysed per participant, ordered by date of sample collection, range 1-3 with oldest to most recent . E.g. some patients had more than one sample analysed collected at different visit dates.
     
wbc continuous no 264 Total white blood cell count (x10^9/L) on day of sample analysed   missing from source database