Dhaka household cholera dataset
Although much focus is placed on cholera epidemics, the greatest burden occurs in settings in which cholera is endemic, including areas of South Asia, Africa and now Haiti1,2. Dhaka, Bangladesh is a megacity that is hyper-endemic for cholera, and experiences two regular seasonal outbreaks of cholera each year3. Despite this, a detailed understanding of the diversity of Vibrio cholerae strains circulating in this setting, and their relationships to annual outbreaks, has not yet been obtained. Here we performed whole-genome sequencing of V. cholerae across several levels of focus and scale, at the maximum possible resolution. We analyzed bacterial isolates to define cholera dynamics at multiple levels, ranging from infection within individuals, to disease dynamics at the household level, to regional and intercontinental cholera transmission. Our analyses provide a genomic framework for understanding cholera diversity and transmission in an endemic setting.
Keywords
Bacterial infection, Microbial geneticsItem Type | Dataset |
---|---|
Capture method | Experiment: Field Intervention |
Date | 6 June 2018 |
Geographical area covered (offline during plugin upgrade) |
North Latitude East Longitude South Latitude West Longitude 23.8778 90.6036 23.6692 90.3365 |
Language(s) of written materials | English |
Creator(s) |
Domman, D, Chowdhury, F, Khan, AI, Dorman, MJ, Mutreja, A, Uddin, MI, Paul, A, Begum, YA, Charles, RC, Calderwood, SB, Bhuiyan, TR, Harris, JB, LaRocque, RC, Ryan, ET, Qadri, F and Thomson, NR |
LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology (-2019) |
Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
Date Deposited | 10 Jul 2018 10:57 |
Last Modified | 08 Jul 2021 12:52 |
Publisher | Figshare |
Explore Further
- Data record - Figshare (Online Data Resource)
- Nature - Supplementary material (Data)
No files available. Please consult associated links.
- Data record - Figshare (Online Data Resource)
- Nature - Supplementary material (Data)