Data from: Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity
Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648 malaria-exposed individuals using lab-based mosquito-feeding assays. Transmission inhibition is significantly associated with antibody responses to Pfs48/45, Pfs230, and to 43 novel gametocyte proteins assessed by protein microarray. In field-based mosquito-feeding assays the likelihood and rate of mosquito infection are significantly lower for individuals reactive to Pfs48/45, Pfs230 or to combinations of the novel TRA-associated proteins. We also show that naturally acquired purified antibodies against key transmission-blocking epitopes of Pfs48/45 and Pfs230 are mechanistically involved in TRA, whereas sera depleted of these antibodies retain high-level, complement-independent TRA. Our analysis demonstrates that host antibody responses to gametocyte proteins are associated with reduced malaria transmission efficiency from humans to mosquitoes.
Keywords
Malaria, Transmission-reducing immunity, Gametocytes, Gametes, Protein microarray, Serology, TransmissionItem Type | Dataset |
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Capture method | Experiment |
Date | 9 February 2018 |
Language(s) of written materials | English |
Creator(s) |
Stone, WJR |
LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology (-2023) Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection (-2019) |
Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
Date Deposited | 16 Feb 2018 17:18 |
Last Modified | 07 Sep 2021 16:18 |
Publisher | Dryad Digital Repository |
Explore Further
- Dryad Digital Repository (Online Data Resource)
- ProteomeXchange Consortium (Data)
- Nature Communications (Data)
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- Dryad Digital Repository (Online Data Resource)
- ProteomeXchange Consortium (Data)
- Nature Communications (Data)