Quantification of huntingtin protein species in Huntington’s disease patient leukocytes using optimised electrochemiluminescence immunoassays

Hensman Moss, DJ; Robertson, N; Farmer, R; Scahill, RI; Haider, S; Tessari, MA; Flynn, G; Fischer, DF; Wild, EJ; Macdonald, D and Tabrizi, SJ (2017). Quantification of huntingtin protein species in Huntington’s disease patient leukocytes using optimised electrochemiluminescence immunoassays. [Dataset]. PLOS One. https://doi.org/10.1371/journal.pone.0189891
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Huntington’s disease (HD) is an autosomal dominant neurodegenerative condition caused by an expanded CAG repeat in the gene encoding huntingtin (HTT). Optimizing peripheral quantification of huntingtin throughout the course of HD is valuable not only to illuminate the natural history and pathogenesis of disease, but also to detect peripheral effects of drugs in clinical trial.

Keywords

Huntington disease; Public and occupational health; Neuroimaging; Blood; Protein concentration assays; Electrochemistry; White blood cells; Immunoassays

Item Type Dataset
Resource Type
Resource Type
Resource Description
Dataset
Quantitative
Capture method Experiment: Laboratory
Date 22 December 2017
Language(s) of written materials English
Creator(s) Hensman Moss, DJ; Robertson, N; Farmer, R; Scahill, RI; Haider, S; Tessari, MA; Flynn, G; Fischer, DF; Wild, EJ; Macdonald, D and Tabrizi, SJ
LSHTM Faculty/Department Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Participating Institutions London School of Hygiene & Tropical Medicine, London, United Kingdom
Funders
Project
Funder
Grant Number
Funder URI
UNSPECIFIED
European Commission
HEALTHF2- 2010-261358
UNSPECIFIED
Date Deposited 02 Feb 2018 14:17
Last Modified 28 Apr 2026 12:39
Publisher PLOS One

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