Quantification of huntingtin protein species in Huntington’s disease patient leukocytes using optimised electrochemiluminescence immunoassays

Hensman Moss, DJ, Robertson, N, Farmer, R, Scahill, RI, Haider, S, Tessari, MA, Flynn, G, Fischer, DF, Wild, EJ, Macdonald, D and Tabrizi, SJ (2017). Quantification of huntingtin protein species in Huntington’s disease patient leukocytes using optimised electrochemiluminescence immunoassays. [Dataset]. PLOS One. https://doi.org/10.1371/journal.pone.0189891
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Huntington’s disease (HD) is an autosomal dominant neurodegenerative condition caused by an expanded CAG repeat in the gene encoding huntingtin (HTT). Optimizing peripheral quantification of huntingtin throughout the course of HD is valuable not only to illuminate the natural history and pathogenesis of disease, but also to detect peripheral effects of drugs in clinical trial.

Keywords

Huntington disease, Public and occupational health, Neuroimaging, Blood, Protein concentration assays, Electrochemistry, White blood cells, Immunoassays

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