Quantification of huntingtin protein species in Huntington’s disease patient leukocytes using optimised electrochemiluminescence immunoassays
Hensman Moss, DJ, Robertson, N, Farmer, R, Scahill, RI, Haider, S, Tessari, MA, Flynn, G, Fischer, DF, Wild, EJ, Macdonald, D and Tabrizi, SJ
(2017).
Quantification of huntingtin protein species in Huntington’s disease patient leukocytes using optimised electrochemiluminescence immunoassays.
[Dataset].
PLOS One.
https://doi.org/10.1371/journal.pone.0189891
Huntington’s disease (HD) is an autosomal dominant neurodegenerative condition caused by an expanded CAG repeat in the gene encoding huntingtin (HTT). Optimizing peripheral quantification of huntingtin throughout the course of HD is valuable not only to illuminate the natural history and pathogenesis of disease, but also to detect peripheral effects of drugs in clinical trial.
Keywords
Huntington disease, Public and occupational health, Neuroimaging, Blood, Protein concentration assays, Electrochemistry, White blood cells, ImmunoassaysItem Type | Dataset |
---|---|
Capture method | Experiment: Laboratory |
Date | 22 December 2017 |
Language(s) of written materials | English |
Creator(s) | Hensman Moss, DJ, Robertson, N, Farmer, R, Scahill, RI, Haider, S, Tessari, MA, Flynn, G, Fischer, DF, Wild, EJ, Macdonald, D and Tabrizi, SJ |
LSHTM Faculty/Department |
Faculty of Epidemiology and Population Health > Dept of Medical Statistics Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology |
Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom |
Funders |
Project Funder Grant Number Funder URI |
Date Deposited | 02 Feb 2018 14:17 |
Last Modified | 27 Apr 2022 18:19 |
Publisher | PLOS One |