A Cross-Sectional Study of ‘Yaws’ in Districts of Ghana Which Have Previously Undertaken Azithromycin Mass Drug Administration for Trachoma Control. Study dataset
, Agana, N, Mabey, D, Chen, C, Adu-Sarkodie, Y and Marks, M
(2015).
A Cross-Sectional Study of ‘Yaws’ in Districts of Ghana Which Have Previously Undertaken Azithromycin Mass Drug Administration for Trachoma Control. Study dataset.
[Dataset].
Figshare.
https://doi.org/10.1371/journal.pntd.0003496.s002
Yaws, caused by Treponema pallidum ssp. pertenue, is reportedly endemic in Ghana. Mass distribution of azithromycin is now the cornerstone of the WHO yaws eradication campaign. Mass distribution of azithromycin at a lower target dose was previously undertaken in two regions of Ghana for the control of trachoma. Ongoing reporting of yaws raises the possibility that resistance may have emerged in T. pallidum pertenue, or that alternative infections may be responsible for some of the reported cases. We conducted a cross-sectional survey in thirty communities in two districts of Ghana where MDA for trachoma had previously been conducted. Children aged 5–17 years with ulcerative lesions compatible with yaws were enrolled. Samples for treponemal serology and lesion PCR were collected from all children. 90 children with 98 lesions were enrolled. Syphilis serology was negative in all of them. PCR for T. pallidum ssp pertenue was negative in all children, but Haemophilus ducreyi DNA was detected in 9 lesions. In these communities, previously treated for trachoma, we found no evidence of ongoing transmission of yaws. H. ducreyi was associated with a proportion of skin lesions, but the majority of lesions remain unexplained. Integration of diagnostic testing into both pre and post-MDA surveillance systems is required to better inform yaws control programmes.
Additional Information
Data held on Figshare
Keywords
Yaws, Lesions, Ulcers, Trachoma, Ghana, Treponema pallidum, Serology, Infectious disease control| Item Type | Dataset |
|---|---|
| Description of data capture | For each participant we collected demographic data including age and gender, as well as data on household size and number of individuals sharing a single room as measures of overcrowding. We collected data on whether any household contacts had been diagnosed with scabies. All participants were then examined by an experienced consultant paediatrician (BTW). We recorded the presence or absence of all skin lesions, their distribution and whether they were consistent with scabies, impetigo or an alternative diagnosis. The number of scabies lesions was classified as ≤10, 11 to 49 or ≥50. Lesions of impetigo were classified as either active (moist, purulent or crusted lesions) or healed (flat/dry lesions with no crust). The number of impetigo lesions was classified as ≤5, 6 to 10, 11 to 49 or ≥50. All data was collected directly on to Android smartphones using the ODK software package |
| Capture method | Questionnaire: Fixed form - Paper, Field observation: Participant |
| Date | 29 January 2015 |
| Geographical area covered (offline during plugin upgrade) |
North Latitude East Longitude South Latitude West Longitude 10.0429 0.178528 9.25766 -0.887146 |
| Language(s) of written materials | English |
| Creator(s) |
Ghinai, R, El-Duah, P, Chi, K, Pillay, A, Solomon, AW, Bailey, R, Agana, N, Mabey, D, Chen, C, Adu-Sarkodie, Y and Marks, M
|
| LSHTM Faculty/Department | Faculty of Infectious and Tropical Diseases > Dept of Clinical Research |
| Participating Institutions | London School of Hygiene & Tropical Medicine, London, United Kingdom, National Referral Hospital, Ministry of Health and Medical Services, Honiara, Solomon Islands, National Health Training Research Institute, Ministry of Health and Medical Services, Honiara, Solomon Islands, University of Melbourne, Melbourne, Victoria, Australia |
| Funders |
Project Funder Grant Number Funder URI |
| Date Deposited | 31 Oct 2017 16:50 |
| Last Modified | 08 Jul 2021 12:52 |
| Publisher | Figshare |
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